Polymeric Nanoparticles for Nonviral Gene Therapy Extend Brain Tumor Survival in Vivo

Biodegradable polymeric nanoparticles have the potential to be safer alternatives to viruses for gene delivery; however, their use has been limited by poor efficacy in vivo. In this work, we synthesize and characterize polymeric gene delivery nanoparticles and evaluate their efficacy for DNA deliver...

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Veröffentlicht in:	ACS nano 2015-02, Vol.9 (2), p.1236-1249
Hauptverfasser:	Mangraviti, Antonella, Tzeng, Stephany Yi, Kozielski, Kristen Lynn, Wang, Yuan, Jin, Yike, Gullotti, David, Pedone, Mariangela, Buaron, Nitsa, Liu, Ann, Wilson, David R, Hansen, Sarah K, Rodriguez, Fausto J, Gao, Guo-Dong, DiMeco, Francesco, Brem, Henry, Olivi, Alessandro, Tyler, Betty, Green, Jordan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - pathology Brain Neoplasms - therapy Cell Death - drug effects Cell Death - genetics Cell Line, Tumor DNA - chemistry DNA - genetics Female Ganciclovir - metabolism Genetic Therapy - methods Glioma - drug therapy Glioma - genetics Glioma - pathology Glioma - therapy Herpesvirus 1, Human - enzymology Herpesvirus 1, Human - genetics Nanomedicine - methods Nanoparticles - chemistry Polymers - chemistry Prodrugs - metabolism Prodrugs - pharmacology Prodrugs - therapeutic use Rats Safety Survival Analysis Thymidine Kinase - genetics Transfection
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