Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury
A model of cerebral ischemia and reperfusion was established in mice.Mice were treated with ketamine via intraperitoneal injection immediately following ischemia or ischemia/reperfusion.Ketamine did not remarkably change infarct volume in mice immediately following ischemia,but injection immediately...
Gespeichert in:
Veröffentlicht in: | Neural regeneration research 2012-04, Vol.7 (11), p.833-836 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 836 |
---|---|
container_issue | 11 |
container_start_page | 833 |
container_title | Neural regeneration research |
container_volume | 7 |
creator | Xiao, Feng Xiong, Liangzhi Wang, Qingxiu Zhou, Long Zhou, Qingshan |
description | A model of cerebral ischemia and reperfusion was established in mice.Mice were treated with ketamine via intraperitoneal injection immediately following ischemia or ischemia/reperfusion.Ketamine did not remarkably change infarct volume in mice immediately following ischemia,but injection immediately following ischemia/reperfusion significantly decreased infarct volume.Ketamine injection immediately after ischemia or ischemia/reperfusion inhibited c-Jun protein expression in mouse hippocampus,but nuclear factor kappa B expression was unaltered.In addition,the Longa scale score for neural impairment was not reduced in mice following cerebral ischemia/reperfusion.These results indicate that ketamine can protect mice against cerebral ischemia and reperfusion injury by modulating c-Jun protein expression in mouse hippocampus. |
doi_str_mv | 10.3969/j.issn.1673-5374.2012.11.006 |
format | Article |
fullrecord | <record><control><sourceid>wanfang_jour_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4342710</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>41822682</cqvip_id><wanfj_id>zgsjzsyj_e201211006</wanfj_id><sourcerecordid>zgsjzsyj_e201211006</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-c2b8289b03ec7e9d70f41100e4af5cb129e2a899560a0f936bd8c6f014e319973</originalsourceid><addsrcrecordid>eNpdkV9v1SAYhxujcXP6FUyNXixZ2vGnQLlZYpbpdEt2o9eEct62NC100DrPPr0s5-xEvYKEhx_P-yPLPmFUUsnl-VDaGF2JuaAFo6IqCcKkxLhEiL_IjnEteCEkq1-m_TNzlL2JcUCI1ZLQ19kRYYIKgdFx5m5g0ZN1kFvX28YuMTfF99Xlc_ALWJfD7zlAjNa7ROSTXyPkvZ1nb_Q0rzFv_Tj6B-u63ECAJugxt9H0MFl9HmCG0K77y8Matm-zV60eI7zbryfZzy9XPy6vi9u7r98uP98WpsJsKQxpalLLBlEwAuRGoLbCGCGodMtMg4kEomspGUcatZLyZlMb3iJcAcVSCnqSXexy57WZYGPALclMzcFOOmyV11b9e-Jsrzr_S1W0IqmYFHC2C3jQrtWuU4Nfg0vK6rGLw2PcDgqein-y4ok-3T8X_P0KcVFTKgHGUTtIjSnMOZIpl7OEfvwPPSQTmoZGlDCaqPd_-x_Enz8uAR92gOm96-5T_wemwjUhvCb0D8gPq5I</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2382803253</pqid></control><display><type>article</type><title>Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury</title><source>Medknow Open Access Medical Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><source>PubMed Central Open Access</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Xiao, Feng ; Xiong, Liangzhi ; Wang, Qingxiu ; Zhou, Long ; Zhou, Qingshan</creator><creatorcontrib>Xiao, Feng ; Xiong, Liangzhi ; Wang, Qingxiu ; Zhou, Long ; Zhou, Qingshan</creatorcontrib><description>A model of cerebral ischemia and reperfusion was established in mice.Mice were treated with ketamine via intraperitoneal injection immediately following ischemia or ischemia/reperfusion.Ketamine did not remarkably change infarct volume in mice immediately following ischemia,but injection immediately following ischemia/reperfusion significantly decreased infarct volume.Ketamine injection immediately after ischemia or ischemia/reperfusion inhibited c-Jun protein expression in mouse hippocampus,but nuclear factor kappa B expression was unaltered.In addition,the Longa scale score for neural impairment was not reduced in mice following cerebral ischemia/reperfusion.These results indicate that ketamine can protect mice against cerebral ischemia and reperfusion injury by modulating c-Jun protein expression in mouse hippocampus.</description><identifier>ISSN: 1673-5374</identifier><identifier>EISSN: 1876-7958</identifier><identifier>DOI: 10.3969/j.issn.1673-5374.2012.11.006</identifier><identifier>PMID: 25737710</identifier><language>eng</language><publisher>India: Medknow Publications & Media Pvt. Ltd</publisher><subject>c-Jun ; Carotid arteries ; Ischemia ; Ketamine ; Kinases ; Laboratory animals ; Medical research ; Protein expression ; Proteins ; Surgery ; Technique and Methods: Brain Injury and Neuroregeneration ; Transcription factors ; Veins & arteries ; 小鼠 ; 核因子kappa ; 氯胺酮 ; 海马 ; 缺血/再灌注损伤 ; 脑缺血再灌注 ; 蛋白表达</subject><ispartof>Neural regeneration research, 2012-04, Vol.7 (11), p.833-836</ispartof><rights>2012. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>Copyright: © Neural Regeneration Research 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-c2b8289b03ec7e9d70f41100e4af5cb129e2a899560a0f936bd8c6f014e319973</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/88507X/88507X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342710/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342710/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25737710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiao, Feng</creatorcontrib><creatorcontrib>Xiong, Liangzhi</creatorcontrib><creatorcontrib>Wang, Qingxiu</creatorcontrib><creatorcontrib>Zhou, Long</creatorcontrib><creatorcontrib>Zhou, Qingshan</creatorcontrib><title>Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury</title><title>Neural regeneration research</title><addtitle>Neural Regeneration Research</addtitle><description>A model of cerebral ischemia and reperfusion was established in mice.Mice were treated with ketamine via intraperitoneal injection immediately following ischemia or ischemia/reperfusion.Ketamine did not remarkably change infarct volume in mice immediately following ischemia,but injection immediately following ischemia/reperfusion significantly decreased infarct volume.Ketamine injection immediately after ischemia or ischemia/reperfusion inhibited c-Jun protein expression in mouse hippocampus,but nuclear factor kappa B expression was unaltered.In addition,the Longa scale score for neural impairment was not reduced in mice following cerebral ischemia/reperfusion.These results indicate that ketamine can protect mice against cerebral ischemia and reperfusion injury by modulating c-Jun protein expression in mouse hippocampus.</description><subject>c-Jun</subject><subject>Carotid arteries</subject><subject>Ischemia</subject><subject>Ketamine</subject><subject>Kinases</subject><subject>Laboratory animals</subject><subject>Medical research</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Surgery</subject><subject>Technique and Methods: Brain Injury and Neuroregeneration</subject><subject>Transcription factors</subject><subject>Veins & arteries</subject><subject>小鼠</subject><subject>核因子kappa</subject><subject>氯胺酮</subject><subject>海马</subject><subject>缺血/再灌注损伤</subject><subject>脑缺血再灌注</subject><subject>蛋白表达</subject><issn>1673-5374</issn><issn>1876-7958</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkV9v1SAYhxujcXP6FUyNXixZ2vGnQLlZYpbpdEt2o9eEct62NC100DrPPr0s5-xEvYKEhx_P-yPLPmFUUsnl-VDaGF2JuaAFo6IqCcKkxLhEiL_IjnEteCEkq1-m_TNzlL2JcUCI1ZLQ19kRYYIKgdFx5m5g0ZN1kFvX28YuMTfF99Xlc_ALWJfD7zlAjNa7ROSTXyPkvZ1nb_Q0rzFv_Tj6B-u63ECAJugxt9H0MFl9HmCG0K77y8Matm-zV60eI7zbryfZzy9XPy6vi9u7r98uP98WpsJsKQxpalLLBlEwAuRGoLbCGCGodMtMg4kEomspGUcatZLyZlMb3iJcAcVSCnqSXexy57WZYGPALclMzcFOOmyV11b9e-Jsrzr_S1W0IqmYFHC2C3jQrtWuU4Nfg0vK6rGLw2PcDgqein-y4ok-3T8X_P0KcVFTKgHGUTtIjSnMOZIpl7OEfvwPPSQTmoZGlDCaqPd_-x_Enz8uAR92gOm96-5T_wemwjUhvCb0D8gPq5I</recordid><startdate>20120415</startdate><enddate>20120415</enddate><creator>Xiao, Feng</creator><creator>Xiong, Liangzhi</creator><creator>Wang, Qingxiu</creator><creator>Zhou, Long</creator><creator>Zhou, Qingshan</creator><general>Medknow Publications & Media Pvt. Ltd</general><general>Department of Anesthesiology, Affiliated Taihe Hospital of Yunyang Medical College, Shiyan 442000, Hubei Province, China%Department of Anesthesiology, Shanghai East Hospital Affiliated to Tongji University, Shanghai 200120, China%Department of Anesthesiology, People's Hospital Affiliated to Wuhan University Medical College, Wuhan 430070, Hubei Province, China</general><general>Medknow Publications & Media Pvt Ltd</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M2M</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20120415</creationdate><title>Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury</title><author>Xiao, Feng ; Xiong, Liangzhi ; Wang, Qingxiu ; Zhou, Long ; Zhou, Qingshan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-c2b8289b03ec7e9d70f41100e4af5cb129e2a899560a0f936bd8c6f014e319973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>c-Jun</topic><topic>Carotid arteries</topic><topic>Ischemia</topic><topic>Ketamine</topic><topic>Kinases</topic><topic>Laboratory animals</topic><topic>Medical research</topic><topic>Protein expression</topic><topic>Proteins</topic><topic>Surgery</topic><topic>Technique and Methods: Brain Injury and Neuroregeneration</topic><topic>Transcription factors</topic><topic>Veins & arteries</topic><topic>小鼠</topic><topic>核因子kappa</topic><topic>氯胺酮</topic><topic>海马</topic><topic>缺血/再灌注损伤</topic><topic>脑缺血再灌注</topic><topic>蛋白表达</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiao, Feng</creatorcontrib><creatorcontrib>Xiong, Liangzhi</creatorcontrib><creatorcontrib>Wang, Qingxiu</creatorcontrib><creatorcontrib>Zhou, Long</creatorcontrib><creatorcontrib>Zhou, Qingshan</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Psychology</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neural regeneration research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiao, Feng</au><au>Xiong, Liangzhi</au><au>Wang, Qingxiu</au><au>Zhou, Long</au><au>Zhou, Qingshan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury</atitle><jtitle>Neural regeneration research</jtitle><addtitle>Neural Regeneration Research</addtitle><date>2012-04-15</date><risdate>2012</risdate><volume>7</volume><issue>11</issue><spage>833</spage><epage>836</epage><pages>833-836</pages><issn>1673-5374</issn><eissn>1876-7958</eissn><abstract>A model of cerebral ischemia and reperfusion was established in mice.Mice were treated with ketamine via intraperitoneal injection immediately following ischemia or ischemia/reperfusion.Ketamine did not remarkably change infarct volume in mice immediately following ischemia,but injection immediately following ischemia/reperfusion significantly decreased infarct volume.Ketamine injection immediately after ischemia or ischemia/reperfusion inhibited c-Jun protein expression in mouse hippocampus,but nuclear factor kappa B expression was unaltered.In addition,the Longa scale score for neural impairment was not reduced in mice following cerebral ischemia/reperfusion.These results indicate that ketamine can protect mice against cerebral ischemia and reperfusion injury by modulating c-Jun protein expression in mouse hippocampus.</abstract><cop>India</cop><pub>Medknow Publications & Media Pvt. Ltd</pub><pmid>25737710</pmid><doi>10.3969/j.issn.1673-5374.2012.11.006</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1673-5374 |
ispartof | Neural regeneration research, 2012-04, Vol.7 (11), p.833-836 |
issn | 1673-5374 1876-7958 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4342710 |
source | Medknow Open Access Medical Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete; PubMed Central Open Access; PubMed Central; Alma/SFX Local Collection |
subjects | c-Jun Carotid arteries Ischemia Ketamine Kinases Laboratory animals Medical research Protein expression Proteins Surgery Technique and Methods: Brain Injury and Neuroregeneration Transcription factors Veins & arteries 小鼠 核因子kappa 氯胺酮 海马 缺血/再灌注损伤 脑缺血再灌注 蛋白表达 |
title | Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T14%3A28%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wanfang_jour_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ketamine%20inhibits%20c-Jun%20protein%20expression%20in%20mouse%20hippocampus%20following%20cerebral%20ischemia/reperfusion%20injury&rft.jtitle=Neural%20regeneration%20research&rft.au=Xiao,%20Feng&rft.date=2012-04-15&rft.volume=7&rft.issue=11&rft.spage=833&rft.epage=836&rft.pages=833-836&rft.issn=1673-5374&rft.eissn=1876-7958&rft_id=info:doi/10.3969/j.issn.1673-5374.2012.11.006&rft_dat=%3Cwanfang_jour_pubme%3Ezgsjzsyj_e201211006%3C/wanfang_jour_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2382803253&rft_id=info:pmid/25737710&rft_cqvip_id=41822682&rft_wanfj_id=zgsjzsyj_e201211006&rfr_iscdi=true |