Genetic Overlap Between Diagnostic Subtypes of Ischemic Stroke

BACKGROUND AND PURPOSE—Despite moderate heritability, the phenotypic heterogeneity of ischemic stroke has hampered gene discovery, motivating analyses of diagnostic subtypes with reduced sample sizes. We assessed evidence for a shared genetic basis among the 3 major subtypeslarge artery atherosclero...

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Veröffentlicht in:	Stroke (1970) 2015-03, Vol.46 (3), p.615-619
Hauptverfasser:	Holliday, Elizabeth G, Traylor, Matthew, Malik, Rainer, Bevan, Steve, Falcone, Guido, Hopewell, Jemma C, Cheng, Yu-Ching, Cotlarciuc, Ioana, Bis, Joshua C, Boerwinkle, Eric, Boncoraglio, Giorgio B, Clarke, Robert, Cole, John W, Fornage, Myriam, Furie, Karen L, Ikram, M Arfan, Jannes, Jim, Kittner, Steven J, Lincz, Lisa F, Maguire, Jane M, Meschia, James F, Mosley, Thomas H, Nalls, Mike A, Oldmeadow, Christopher, Parati, Eugenio A, Psaty, Bruce M, Rothwell, Peter M, Seshadri, Sudha, Scott, Rodney J, Sharma, Pankaj, Sudlow, Cathie, Wiggins, Kerri L, Worrall, Bradford B, Rosand, Jonathan, Mitchell, Braxton D, Dichgans, Martin, Markus, Hugh S, Levi, Christopher, Attia, John, Wray, Naomi R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Atherosclerosis - diagnosis Atherosclerosis - genetics Cerebral Small Vessel Diseases - diagnosis Cerebral Small Vessel Diseases - genetics Cohort Studies Data Interpretation, Statistical Embolism - diagnosis Embolism - genetics Genome-Wide Association Study Genotype Humans Ischemia - diagnosis Ischemia - genetics Linear Models Meta-Analysis as Topic Phenotype Polymorphism, Single Nucleotide Stroke - diagnosis Stroke - genetics
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