Barberry administration and pro-oxidant–antioxidant balance in patients with metabolic syndrome

Background : Metabolic syndrome is the constellation of several cardiometabolic risk factors, and is associated with a heightened risk of coronary heart disease (CHD). The pro-oxidant–antioxidant balance (PAB) is a measure of factors that promote and control oxidative stress. PAB may also be associa...

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Veröffentlicht in:Iranian red crescent medical journal 2014-12, Vol.16 (12), p.1-5
Hauptverfasser: Sahibkar, Amir Husayn, Kermani, Tayyebeh, Zhilaee, Marzieh, Tavallaie, Shima, Ghayour Mobarhan, Majid, Mohammadi, Akram
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container_end_page 5
container_issue 12
container_start_page 1
container_title Iranian red crescent medical journal
container_volume 16
creator Sahibkar, Amir Husayn
Kermani, Tayyebeh
Zhilaee, Marzieh
Tavallaie, Shima
Ghayour Mobarhan, Majid
Mohammadi, Akram
description Background : Metabolic syndrome is the constellation of several cardiometabolic risk factors, and is associated with a heightened risk of coronary heart disease (CHD). The pro-oxidant–antioxidant balance (PAB) is a measure of factors that promote and control oxidative stress. PAB may also be associated with the risk factors of CHD. Objectives : This study aimed to explore the impact of supplementation with barberry, a fruit rich in antioxidants, on PAB in patients with metabolic syndrome. Patients and Methods: A total of 106 patients diagnosed with metabolic syndrome were randomized in two groups: case and control. The case group received three capsules of barberry and the control group received three capsules of placebo for 6 weeks. Serum PAB was measured in all patients before and after the intervention. Results : There was no significant difference between the groups regarding their baseline PAB values (P = 0.32). A significant decrease in PAB was observed in the barberry group (P = 0.022), whilst there was no significant change in the control group (P = 0.18). The magnitude of change in PAB during the study was significantly greater in the case group compared to the control group (P = 0.01). Conclusions : Barberry supplementation reduces oxidative burden in patients with metabolic syndrome.
doi_str_mv 10.5812/ircmj.16786
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The pro-oxidant–antioxidant balance (PAB) is a measure of factors that promote and control oxidative stress. PAB may also be associated with the risk factors of CHD. Objectives : This study aimed to explore the impact of supplementation with barberry, a fruit rich in antioxidants, on PAB in patients with metabolic syndrome. Patients and Methods: A total of 106 patients diagnosed with metabolic syndrome were randomized in two groups: case and control. The case group received three capsules of barberry and the control group received three capsules of placebo for 6 weeks. Serum PAB was measured in all patients before and after the intervention. Results : There was no significant difference between the groups regarding their baseline PAB values (P = 0.32). A significant decrease in PAB was observed in the barberry group (P = 0.022), whilst there was no significant change in the control group (P = 0.18). The magnitude of change in PAB during the study was significantly greater in the case group compared to the control group (P = 0.01). 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The pro-oxidant–antioxidant balance (PAB) is a measure of factors that promote and control oxidative stress. PAB may also be associated with the risk factors of CHD. Objectives : This study aimed to explore the impact of supplementation with barberry, a fruit rich in antioxidants, on PAB in patients with metabolic syndrome. Patients and Methods: A total of 106 patients diagnosed with metabolic syndrome were randomized in two groups: case and control. The case group received three capsules of barberry and the control group received three capsules of placebo for 6 weeks. Serum PAB was measured in all patients before and after the intervention. Results : There was no significant difference between the groups regarding their baseline PAB values (P = 0.32). A significant decrease in PAB was observed in the barberry group (P = 0.022), whilst there was no significant change in the control group (P = 0.18). The magnitude of change in PAB during the study was significantly greater in the case group compared to the control group (P = 0.01). 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subjects Barberries
Diagnosis
Metabolic syndrome
Oxidative stress
Therapeutic use
الإجهاد التأكسدي
التشخيص
title Barberry administration and pro-oxidant–antioxidant balance in patients with metabolic syndrome
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