Structural and functional substrates of tetanus toxin in an animal model of temporal lobe epilepsy

The effects of tetanus toxin (TeNT) both in the spinal cord, in clinical tetanus, and in the brain, in experimental focal epilepsy, suggest disruption of inhibitory synapses. TeNT is a zinc protease with selectivity for Vesicle Associated Membrane Protein (VAMP; previously synaptobrevin), with a rep...

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Veröffentlicht in:	Brain Structure and Function 2015-03, Vol.220 (2), p.1013-1029
Hauptverfasser:	Ferecskó, Alex S., Jiruska, Premysl, Foss, Lucy, Powell, Andrew D., Chang, Wei-Chih, Sik, Attila, Jefferys, John G. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal Biomedical and Life Sciences Biomedicine Brain Brain Waves Cell Biology Disease Models, Animal Epilepsy Epilepsy, Temporal Lobe - chemically induced Epilepsy, Temporal Lobe - metabolism Epilepsy, Temporal Lobe - physiopathology Excitatory Postsynaptic Potentials Hippocampus - metabolism Hippocampus - physiopathology Inhibitory Postsynaptic Potentials Male Neural Inhibition Neurology Neurosciences Original Original Article Rats, Sprague-Dawley Rodents Signal Transduction Temporal Lobe - metabolism Temporal Lobe - physiopathology Tetanus Tetanus Toxin Time Factors Vesicle-Associated Membrane Protein 1 - metabolism Vesicle-Associated Membrane Protein 2 - metabolism
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