Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory

The authors show that astrocytes produce high levels of the adenosine receptor A2A in Alzheimer brains. Reducing the levels of astrocytic A2A boosted memory in young and aging mice and mouse models of Alzheimer disease, whereas activating a related molecular pathway impaired memory. Thus, astrocytes...

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Veröffentlicht in:	Nature neuroscience 2015-03, Vol.18 (3), p.423-434
Hauptverfasser:	Orr, Anna G, Hsiao, Edward C, Wang, Max M, Ho, Kaitlyn, Kim, Daniel H, Wang, Xin, Guo, Weikun, Kang, Jing, Yu, Gui-Qiu, Adame, Anthony, Devidze, Nino, Dubal, Dena B, Masliah, Eliezer, Conklin, Bruce R, Mucke, Lennart
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/51 45/88 631/378/1595/2167 631/378/1689/1283 631/378/2596/1308 631/80/304 64/110 96/106 96/63 Ablation Adenosine Aging Alzheimer Disease - pathology Alzheimer's disease Animal Genetics and Genomics Animals Animals, Newborn Astrocytes - metabolism Behavioral Sciences Biological Techniques Biomedicine Brain Cognitive ability Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Exploratory Behavior - drug effects Exploratory Behavior - physiology Gene Expression Regulation - physiology Glial Fibrillary Acidic Protein - genetics Glial Fibrillary Acidic Protein - metabolism Humans Indoles - pharmacology Maze Learning - physiology Memory Memory, Long-Term - physiology Mice Mice, Inbred C57BL Mice, Transgenic Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurobiology Neurosciences Pathology Proteins Receptor, Adenosine A2A - genetics Receptor, Adenosine A2A - metabolism Receptors, Serotonin, 5-HT4 - genetics Receptors, Serotonin, 5-HT4 - metabolism Recognition, Psychology - drug effects Recognition, Psychology - physiology Serotonin Antagonists - pharmacology Signal Transduction - physiology Sulfonamides - pharmacology
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