Mechanical and non-mechanical functions of Dystrophin can prevent cardiac abnormalities in Drosophila

Dystrophin-deficiency causes cardiomyopathies and shortens the life expectancy of Duchenne and Becker muscular dystrophy patients. Restoring Dystrophin expression in the heart by gene transfer is a promising avenue to explore as a therapy. Truncated Dystrophin gene constructs have been engineered an...

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Veröffentlicht in:	Experimental gerontology 2014-01, Vol.49, p.26-34
Hauptverfasser:	Taghli-Lamallem, Ouarda, Jagla, Krzysztof, Chamberlain, Jeffrey S., Bodmer, Rolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - genetics Aging - physiology Animals Animals, Genetically Modified Cardiomyopathy, Dilated - genetics Cardiomyopathy, Dilated - metabolism Cardiomyopathy, Dilated - prevention & control Drosophila - genetics Drosophila - metabolism Dystroglycans - physiology Dystrophin - deficiency Dystrophin - genetics Dystrophin - physiology Genetic Therapy - methods Heart period Micro-Dystrophins Mutation Myocytes, Cardiac - metabolism Myofibrils Nitric oxide synthase Nitric Oxide Synthase - metabolism Nitric Oxide Synthase - physiology Signal Transduction - physiology
Online-Zugang:	Volltext
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