The cardiac protein αT-catenin contributes to chemical-induced asthma

Ten to 25% of adult asthma is occupational induced, a subtype caused by exposure to workplace chemicals. A recent genomewide association study identified single-nucleotide polymorphisms in the cardiac protein αT-catenin (αT-cat) that correlated with the incidence and severity of toluene diisocyanate...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2015-02, Vol.308 (3), p.L253-L258
Hauptverfasser:	Folmsbee, Stephen Sai, Morales-Nebreda, Luisa, Van Hengel, Jolanda, Tyberghein, Koen, Van Roy, Frans, Budinger, G R Scott, Bryce, Paul J, Gottardi, Cara J
Format:	Artikel
Sprache:	eng
Schlagworte:	Air Pollutants - toxicity alpha Catenin - metabolism Animals Asthma, Occupational - chemically induced Asthma, Occupational - metabolism Cells, Cultured Female Humans Intercellular Junctions - metabolism Lung - blood supply Lung - metabolism Lung - pathology Mice, Inbred C57BL Mice, Knockout Myocytes, Cardiac - metabolism Pulmonary Veins - metabolism Pulmonary Veins - pathology Rapid Reports Toluene 2,4-Diisocyanate - toxicity
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