The cochlear sensory epithelium derives from Wnt responsive cells in the dorsomedial otic cup

Wnt1 and Wnt3a secreted from the dorsal neural tube were previously shown to regulate a gene expression program in the dorsal otic vesicle that is necessary for vestibular morphogenesis (Riccomagno et al., 2005. Genes Dev. 19, 1612–1623). Unexpectedly, Wnt1−/−; Wnt3a−/− embryos also displayed a pron...

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Veröffentlicht in:	Developmental biology 2015-03, Vol.399 (1), p.177-187
Hauptverfasser:	Brown, Alexander S., Rakowiecki, Staci M., Li, James Y.H., Epstein, Douglas J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Lineage - genetics Cell Movement - genetics Cell Proliferation - genetics Cochlea Cochlea - cytology Cochlea - embryology Cochlea - metabolism Ear, Inner - cytology Ear, Inner - embryology Ear, Inner - metabolism Embryo, Mammalian - drug effects Embryo, Mammalian - embryology Embryo, Mammalian - metabolism epithelium Epithelium - embryology Epithelium - metabolism Estrogen Antagonists - pharmacology Fate map Female gene expression Gene Expression Regulation, Developmental genes Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Immunohistochemistry In Situ Hybridization Inner ear Male Mice, Transgenic Microscopy, Confocal morphogenesis Morphogenesis - drug effects Morphogenesis - genetics Sensory progenitors tamoxifen Tamoxifen - pharmacology Time Factors Wnt signaling Wnt Signaling Pathway - genetics
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