A THEMIS:SHP1 complex promotes T-cell survival

THEMIS is critical for conventional T‐cell development, but its precise molecular function remains elusive. Here, we show that THEMIS constitutively associates with the phosphatases SHP1 and SHP2. This complex requires the adapter GRB2, which bridges SHP to THEMIS in a Tyr‐phosphorylation‐independen...

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Veröffentlicht in:	The EMBO journal 2015-02, Vol.34 (3), p.393-409
Hauptverfasser:	Paster, Wolfgang, Bruger, Annika M, Katsch, Kristin, Grégoire, Claude, Roncagalli, Romain, Fu, Guo, Gascoigne, Nicholas RJ, Nika, Konstantina, Cohnen, Andre, Feller, Stephan M, Simister, Philip C, Molder, Kelly C, Cordoba, Shaun-Paul, Dushek, Omer, Malissen, Bernard, Acuto, Oreste
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis CD3 Complex - genetics CD3 Complex - metabolism Cell Differentiation - genetics Cell Survival - genetics EMBO07 EMBO19 EMBO37 GRB2 Adaptor Protein - genetics GRB2 Adaptor Protein - metabolism Humans Immune system Intercellular Signaling Peptides and Proteins Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Jurkat Cells Ligands Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism Mass spectrometry Mice Mice, Knockout Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Mutation negative feedback Phosphatase Phosphorylation Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism Proteins - genetics Proteins - metabolism Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - metabolism SHP1 Signal Transduction src Homology Domains T cell receptors T-Lymphocytes - cytology T-Lymphocytes - metabolism TCR THEMIS
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