Carboxypeptidase N-deficient mice present with polymorphic disease phenotypes on induction of experimental autoimmune encephalomyelitis

Abstract Carboxypeptidase N (CPN) is a member of the carboxypeptidase family of enzymes that cleave carboxy-terminal lysine and arginine residues from a large number of biologically active peptides and proteins. These enzymes are best known for their roles in modulating the activity of kinins, compl...

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Veröffentlicht in:	Immunobiology (1979) 2014-02, Vol.219 (2), p.104-108
Hauptverfasser:	Hu, Xianzhen, Wetsel, Rick A, Ramos, Theresa N, Mueller-Ortiz, Stacey L, Schoeb, Trenton R, Barnum, Scott R
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Allergy and Immunology Animals Carboxypeptidase Cell Movement - genetics Demyelinating disease Demyelinating Diseases - genetics Disease Models, Animal Disease Progression Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - metabolism Humans Inflammation - genetics Kinins Leukocytes - immunology Lysine Carboxypeptidase - genetics Lysine Carboxypeptidase - metabolism Meninges - pathology Mice, Inbred C57BL MS/EAE Multiple Sclerosis - genetics Multiple Sclerosis - metabolism Phenotype Spinal Cord - pathology
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