HER2 activation results in β-catenin-dependent changes in pulmonary epithelial permeability

The receptor tyrosine kinase human epidermal growth factor receptor-2 (HER2) is known to regulate pulmonary epithelial barrier function; however, the mechanisms behind this effect remain unidentified. We hypothesized that HER2 signaling alters the epithelial barrier through an interaction with the a...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2015-01, Vol.308 (2), p.L199-L207
Hauptverfasser:	Finigan, James H, Vasu, Vihas T, Thaikoottathil, Jyoti V, Mishra, Rangnath, Shatat, Mohammad A, Mason, Robert J, Kern, Jeffrey A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adherens Junctions - metabolism beta Catenin - genetics beta Catenin - metabolism Cell Adhesion - physiology Cell Line Electric Impedance Enzyme Activation Humans Lung - physiology Neuregulin-1 - metabolism Permeability Phosphorylation Protein Kinase Inhibitors - pharmacology Quinazolines - pharmacology Receptor, ErbB-2 - antagonists & inhibitors Receptor, ErbB-2 - metabolism Respiratory Mucosa - metabolism RNA Interference RNA, Small Interfering Signal Transduction Tight Junctions - metabolism
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