Myeloid‐derived suppressor cells regulate T cell and B cell responses during autoimmune disease

M‐MDSCs inhibit autoreactive T and B cell function; reconstitution of CCR2‐deficient or wild‐type mice with M‐MDSCs ameliorates autoimmune arthritis. MDSCs are a heterogeneous group of myeloid cells that suppress T cell activity in cancer and autoimmune disease. The effect of MDSCs on B cell functio...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of leukocyte biology 2015-03, Vol.97 (3), p.573-582
Hauptverfasser:	Crook, Kristen R., Jin, Mengyao, Weeks, Michael F., Rampersad, Rishi R., Baldi, Robert M., Glekas, Amy S., Shen, Yajuan, Esserman, Denise A., Little, Paul, Schwartz, Todd A., Liu, Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation - immunology Arthritis, Experimental - immunology Arthritis, Experimental - pathology Arthritis, Experimental - therapy autoimmune arthritis Autoimmune Diseases - immunology Autoimmune Diseases - pathology Autoimmune Diseases - therapy B-Lymphocytes - immunology CD4-Positive T-Lymphocytes - immunology Cell Proliferation chemokine receptor collagen‐induced arthritis Dinoprostone - metabolism Female Host Defense & Pathophysiology Immunization immunotherapy Interferon-gamma - metabolism Interleukin-17 - metabolism Male Mice, Inbred C57BL Mice, Inbred DBA Monocytes - pathology Myeloid Cells - immunology Myeloid Cells - transplantation Nitric Oxide Synthase Type II - metabolism Phenotype Receptors, CCR2 - deficiency Receptors, CCR2 - metabolism rheumatoid arthritis T-Lymphocytes - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!