Ask1 gene deletion blocks maternal diabetes-induced endoplasmic reticulum stress in the developing embryo by disrupting the unfolded protein response signalosome

Apoptosis signal-regulating kinase 1 (ASK1) is activated by various stresses. The link between ASK1 activation and endoplasmic reticulum (ER) stress, two causal events in diabetic embryopathy, has not been determined. We sought to investigate whether ASK1 is involved in the unfolded protein response...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2015-03, Vol.64 (3), p.973-988
Hauptverfasser:	Wang, Fang, Wu, Yanqing, Gu, Hui, Reece, E Albert, Fang, Shengyun, Gabbay-Benziv, Rinat, Aberdeen, Graham, Yang, Peixin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Carrier Proteins - genetics Carrier Proteins - metabolism Cells, Cultured Diabetes Diabetes, Gestational - genetics Diabetes, Gestational - metabolism Diabetes, Gestational - pathology Endoplasmic reticulum Endoplasmic Reticulum Stress - genetics Endoplasmic Reticulum Stress - physiology Endoribonucleases - genetics Endoribonucleases - metabolism Female Gene expression Immunoprecipitation In Situ Nick-End Labeling Kinases MAP Kinase Kinase Kinase 5 - deficiency MAP Kinase Kinase Kinase 5 - genetics MAP Kinase Kinase Kinase 5 - metabolism Mice Mice, Inbred C57BL Mice, Knockout Pathophysiology Phosphorylation Pregnancy Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Real-Time Polymerase Chain Reaction Stress response Thioredoxins - genetics Thioredoxins - metabolism Unfolded Protein Response - genetics Unfolded Protein Response - physiology
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