Novel Nrf2 activators from microbial transformation products inhibit blood–retinal barrier permeability in rabbits

Background and Purpose Nuclear factor erythroid 2‐related factor 2 (Nrf2) is a redox‐sensitive transcription factor that binds to antioxidant response elements located in the promoter region of genes encoding many antioxidant enzymes and phase II detoxifying enzymes. Activation of the Nrf2 pathway s...

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Veröffentlicht in:	British journal of pharmacology 2015-03, Vol.172 (5), p.1237-1249
Hauptverfasser:	Nakagami, Yasuhiro, Masuda, Kayoko, Hatano, Emiko, Inoue, Tatsuya, Matsuyama, Takuya, Iizuka, Mayumi, Ono, Yasunori, Ohnuki, Takashi, Murakami, Yoko, Iwasaki, Masaru, Yoshida, Kazuhiro, Kasuya, Yuji, Komoriya, Satoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Blood-Retinal Barrier - drug effects Cell Line Enzymes Female Humans Male Mice NF-E2-Related Factor 2 - metabolism Oxygen - toxicity Permeability Permeability - drug effects Rabbits Rats Rats, Sprague-Dawley Research Papers Retinopathy of Prematurity - chemically induced Retinopathy of Prematurity - pathology Serum Albumin - antagonists & inhibitors Serum Albumin - toxicity Triterpenes - chemistry Triterpenes - pharmacology
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