Local hemostasis, immunothrombosis, and systemic disseminated intravascular coagulation in trauma and traumatic shock

Knowing the pathophysiology of trauma-induced coagulopathy is important for the management of severely injured trauma patients. The aims of this review are to provide a summary of the recent advances in our understanding of thrombosis and hemostasis following trauma and to discuss the pathogenesis o...

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Veröffentlicht in:	Critical care (London, England) England), 2015-02, Vol.19 (1), p.72-72, Article 72
Hauptverfasser:	Gando, Satoshi, Otomo, Yasuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis Animals Anticoagulants Antithrombins - metabolism Blood clot Complications and side effects Critical care Cytokines Deoxyribonucleic acid Disseminated intravascular coagulation Disseminated Intravascular Coagulation - diagnosis Disseminated Intravascular Coagulation - metabolism Disseminated Intravascular Coagulation - physiopathology DNA DNA, Mitochondrial - metabolism Endothelium Fibrin Fibrinolysis - physiology Hemostasis - physiology Histones - metabolism HMGB1 Protein - metabolism Humans Immune response Immunity, Innate - physiology Inflammation Lipoproteins - metabolism Mitochondrial DNA Multiple organ dysfunction syndrome Neutrophils Nucleosomes - metabolism Pathogens Physiological aspects Protein C - metabolism Protein S - metabolism Proteins Review Risk factors Sepsis Shock, Traumatic - metabolism Shock, Traumatic - physiopathology Signal transduction Thrombin Thrombin - metabolism Thrombomodulin - physiology Thrombosis Thrombosis - metabolism Thrombosis - physiopathology Trauma Wound Healing - physiology Wounds and Injuries - metabolism Wounds and Injuries - physiopathology
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