The Mechanisms of RNA SHAPE Chemistry

The biological functions of RNA are ultimately governed by the local environment at each nucleotide. Selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE) chemistry is a powerful approach for measuring nucleotide structure and dynamics in diverse biological environments. SHAPE reagent...

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Veröffentlicht in:	Journal of the American Chemical Society 2012-04, Vol.134 (15), p.6617-6624
Hauptverfasser:	McGinnis, Jennifer L., Dunkle, Jack A., Cate, Jamie H. D., Weeks, Kevin M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Hydroxyl Radical Nucleic Acid Conformation RNA - chemistry RNA, Ribosomal - chemistry
Online-Zugang:	Volltext
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