Granulocyte-macrophage colony-stimulating factor-transfected bone marrow stromal cells for the treatment of ischemic stroke
Adult, male, Sprague-Dawley rats were injected with granulocyte-macrophage colony-stimulating factor-transfected bone marrow stromal cells （GM-CSF-BMSCs） into the ischemic boundary zone at 24 hours after onset of middle cerebral artery occlusion. Results showed reduced infarct volume, decreased numb...
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| Veröffentlicht in: | Neural regeneration research 2012-06, Vol.7 (16), p.1220-1227 |
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| creator | Lin, Xingjian Zhang, Yingdong Liu, Weiguo Dong, Jingde Lu, Jie Di, Qing Shi, Jingping |
| description | Adult, male, Sprague-Dawley rats were injected with granulocyte-macrophage colony-stimulating factor-transfected bone marrow stromal cells （GM-CSF-BMSCs） into the ischemic boundary zone at 24 hours after onset of middle cerebral artery occlusion. Results showed reduced infarct volume, decreased number of apoptotic cells, improved neurological functions, increased angiogenic factor expression, and increased vascular density in the ischemic boundary zone in rats that underwent GM-CSF-BMSCs transplantation compared with the BMSCs group. Experimental findings suggested that GM-CSF-BMSCs could serve as a potential therapeutic strategy for ischemic stroke and are superior to BMSCs alone. |
| doi_str_mv | 10.3969/j.issn.1673-5374.2012.16.003 |
| format | Article |
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Results showed reduced infarct volume, decreased number of apoptotic cells, improved neurological functions, increased angiogenic factor expression, and increased vascular density in the ischemic boundary zone in rats that underwent GM-CSF-BMSCs transplantation compared with the BMSCs group. Experimental findings suggested that GM-CSF-BMSCs could serve as a potential therapeutic strategy for ischemic stroke and are superior to BMSCs alone.</description><identifier>ISSN: 1673-5374</identifier><identifier>EISSN: 1876-7958</identifier><identifier>DOI: 10.3969/j.issn.1673-5374.2012.16.003</identifier><identifier>PMID: 25709619</identifier><language>eng</language><publisher>India: Medknow Publications & Media Pvt. Ltd</publisher><subject>Apoptosis ; Bone marrow ; Cell growth ; Cytokines ; GM-CSF ; Granulocytes ; Ischemia ; Research and Report: Stem Cells and Neural Regeneration ; Spinal cord injuries ; Stroke ; Traumatic brain injury ; Vascular endothelial growth factor ; 中风 ; 巨噬细胞集落刺激因子 ; 干细胞治疗 ; 粒细胞 ; 缺血 ; 转染 ; 骨髓基质干细胞</subject><ispartof>Neural regeneration research, 2012-06, Vol.7 (16), p.1220-1227</ispartof><rights>2012. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>Copyright: © Neural Regeneration Research 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/88507X/88507X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336955/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336955/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25709619$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Xingjian</creatorcontrib><creatorcontrib>Zhang, Yingdong</creatorcontrib><creatorcontrib>Liu, Weiguo</creatorcontrib><creatorcontrib>Dong, Jingde</creatorcontrib><creatorcontrib>Lu, Jie</creatorcontrib><creatorcontrib>Di, Qing</creatorcontrib><creatorcontrib>Shi, Jingping</creatorcontrib><title>Granulocyte-macrophage colony-stimulating factor-transfected bone marrow stromal cells for the treatment of ischemic stroke</title><title>Neural regeneration research</title><addtitle>Neural Regeneration Research</addtitle><description>Adult, male, Sprague-Dawley rats were injected with granulocyte-macrophage colony-stimulating factor-transfected bone marrow stromal cells （GM-CSF-BMSCs） into the ischemic boundary zone at 24 hours after onset of middle cerebral artery occlusion. Results showed reduced infarct volume, decreased number of apoptotic cells, improved neurological functions, increased angiogenic factor expression, and increased vascular density in the ischemic boundary zone in rats that underwent GM-CSF-BMSCs transplantation compared with the BMSCs group. Experimental findings suggested that GM-CSF-BMSCs could serve as a potential therapeutic strategy for ischemic stroke and are superior to BMSCs alone.</description><subject>Apoptosis</subject><subject>Bone marrow</subject><subject>Cell growth</subject><subject>Cytokines</subject><subject>GM-CSF</subject><subject>Granulocytes</subject><subject>Ischemia</subject><subject>Research and Report: Stem Cells and Neural Regeneration</subject><subject>Spinal cord injuries</subject><subject>Stroke</subject><subject>Traumatic brain injury</subject><subject>Vascular endothelial growth factor</subject><subject>中风</subject><subject>巨噬细胞集落刺激因子</subject><subject>干细胞治疗</subject><subject>粒细胞</subject><subject>缺血</subject><subject>转染</subject><subject>骨髓基质干细胞</subject><issn>1673-5374</issn><issn>1876-7958</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkUtv1TAQhSMEoqXwF5ARLJBQgh_xI5tKqIKCVIkNrC3HmbxI7Fvbobrlz-Ny2ytg5bH8zZnjOUXxhuCKNaJ5P1dTjK4iQrKSM1lXFBOarxXG7FFxSpQUpWy4epzrB-akeBbjjDFXDWVPixPKJW4EaU6LX5fBuG3xdp-gXI0NfjeaAZD1i3f7MqZp3RaTJjeg3tjkQ5lyQ-zBJuhQ6x2g1YTgb1BMwa9mQRaWJaLeB5RGQCmASSu4hHyPpmhHWCf7h_0Bz4snvVkivLg_z4rvnz5-u_hcXn29_HLx4aq0jItUMtUbzBTUnEuoBREgbMsNpYriVvaNwrxrW9l0NbTAcdcq0jdcdhnnRnWYnRXnB93d1q7Q2ewmmEXvwpSt77U3k_73xU2jHvxPXTMmGs6zwLuDwI1xvXGDnv0WXLasb4c438b9rOEuBSJyBpl-ez8u-OsNYtJr_njeinHgt6iJ4KomQtA6o6__Q4_KlCmqsKrlHfXyb_9H4w8pZuDVAbCjd8N1DuvI1DSvDUvFfgOi_rD4</recordid><startdate>20120605</startdate><enddate>20120605</enddate><creator>Lin, Xingjian</creator><creator>Zhang, Yingdong</creator><creator>Liu, Weiguo</creator><creator>Dong, Jingde</creator><creator>Lu, Jie</creator><creator>Di, Qing</creator><creator>Shi, Jingping</creator><general>Medknow Publications & Media Pvt. Ltd</general><general>Nanjing Medical University, Affiliated Nanjing First Hospital, Department of Neurology, Nanjing 210029, Jiangsu Province, China</general><general>Nanjing Medical University, Affiliated Nanjing Brain Hospital, Department of Neurology, Nanjing 210029, Jiangsu Province, China%Nanjing Medical University, Affiliated Nanjing Brain Hospital, Department of Neurology, Nanjing 210029, Jiangsu Province, China</general><general>Medknow Publications & Media Pvt Ltd</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M2M</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20120605</creationdate><title>Granulocyte-macrophage colony-stimulating factor-transfected bone marrow stromal cells for the treatment of ischemic stroke</title><author>Lin, Xingjian ; Zhang, Yingdong ; Liu, Weiguo ; Dong, Jingde ; Lu, Jie ; Di, Qing ; Shi, Jingping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-38fa038e4557e4616e6cb5a22820b7f9805dbb79d4ebe50db81f957d5575a8d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Apoptosis</topic><topic>Bone marrow</topic><topic>Cell growth</topic><topic>Cytokines</topic><topic>GM-CSF</topic><topic>Granulocytes</topic><topic>Ischemia</topic><topic>Research and Report: Stem Cells and Neural Regeneration</topic><topic>Spinal cord injuries</topic><topic>Stroke</topic><topic>Traumatic brain injury</topic><topic>Vascular endothelial growth factor</topic><topic>中风</topic><topic>巨噬细胞集落刺激因子</topic><topic>干细胞治疗</topic><topic>粒细胞</topic><topic>缺血</topic><topic>转染</topic><topic>骨髓基质干细胞</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Xingjian</creatorcontrib><creatorcontrib>Zhang, Yingdong</creatorcontrib><creatorcontrib>Liu, Weiguo</creatorcontrib><creatorcontrib>Dong, Jingde</creatorcontrib><creatorcontrib>Lu, Jie</creatorcontrib><creatorcontrib>Di, Qing</creatorcontrib><creatorcontrib>Shi, Jingping</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neural regeneration research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Xingjian</au><au>Zhang, Yingdong</au><au>Liu, Weiguo</au><au>Dong, Jingde</au><au>Lu, Jie</au><au>Di, Qing</au><au>Shi, Jingping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Granulocyte-macrophage colony-stimulating factor-transfected bone marrow stromal cells for the treatment of ischemic stroke</atitle><jtitle>Neural regeneration research</jtitle><addtitle>Neural Regeneration Research</addtitle><date>2012-06-05</date><risdate>2012</risdate><volume>7</volume><issue>16</issue><spage>1220</spage><epage>1227</epage><pages>1220-1227</pages><issn>1673-5374</issn><eissn>1876-7958</eissn><abstract>Adult, male, Sprague-Dawley rats were injected with granulocyte-macrophage colony-stimulating factor-transfected bone marrow stromal cells （GM-CSF-BMSCs） into the ischemic boundary zone at 24 hours after onset of middle cerebral artery occlusion. Results showed reduced infarct volume, decreased number of apoptotic cells, improved neurological functions, increased angiogenic factor expression, and increased vascular density in the ischemic boundary zone in rats that underwent GM-CSF-BMSCs transplantation compared with the BMSCs group. Experimental findings suggested that GM-CSF-BMSCs could serve as a potential therapeutic strategy for ischemic stroke and are superior to BMSCs alone.</abstract><cop>India</cop><pub>Medknow Publications & Media Pvt. Ltd</pub><pmid>25709619</pmid><doi>10.3969/j.issn.1673-5374.2012.16.003</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Neural regeneration research, 2012-06, Vol.7 (16), p.1220-1227 |
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| language | eng |
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| subjects | Apoptosis Bone marrow Cell growth Cytokines GM-CSF Granulocytes Ischemia Research and Report: Stem Cells and Neural Regeneration Spinal cord injuries Stroke Traumatic brain injury Vascular endothelial growth factor 中风 巨噬细胞集落刺激因子 干细胞治疗 粒细胞 缺血 转染 骨髓基质干细胞 |
| title | Granulocyte-macrophage colony-stimulating factor-transfected bone marrow stromal cells for the treatment of ischemic stroke |
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