The chemokine (CCL2-CCR2) signaling axis mediates perineural invasion

Perineural invasion is a form of cancer progression where cancer cells invade along nerves. This behavior is associated with poor clinical outcomes; therefore, it is critical to identify novel ligand-receptor interactions between nerves and cancer cells that support the process of perineural invasio...

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Veröffentlicht in:	Molecular cancer research 2015-02, Vol.13 (2), p.380-390
Hauptverfasser:	He, Shizhi, He, Shuangba, Chen, Chun-Hao, Deborde, Sylvie, Bakst, Richard L, Chernichenko, Natalya, McNamara, William F, Lee, Sei Young, Barajas, Fernando, Yu, Zhenkun, Al-Ahmadie, Hikmat A, Wong, Richard J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cells, Cultured Chemokine CCL2 - metabolism Coculture Techniques Ganglia, Spinal - cytology Ganglia, Spinal - metabolism Ganglia, Spinal - pathology Humans Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Neoplasm Invasiveness Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Receptors, CCR2 - metabolism Signal Transduction
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