Depletion of regulatory T cells decreases cardiac parasitosis and inflammation in experimental Chagas disease

Infection with the protozoan parasite Trypanosoma cruzi may lead to a potentially fatal cardiomyopathy known as Chagas heart disease. This disease is characterized by infiltration of the myocardium by mononuclear cells, including CD4+ T cells, together with edema, myofibrillary destruction, and fibr...

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Veröffentlicht in:	Parasitology research (1987) 2015-03, Vol.114 (3), p.1167-1178
Hauptverfasser:	Bonney, Kevin M, Taylor, Joann M, Thorp, Edward B, Epting, Conrad L, Engman, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	adjuvants Animals Biomedical and Life Sciences Biomedicine cardiomyopathy CD4-positive T-lymphocytes Chagas disease Chagas Disease - parasitology Chagas Disease - pathology edema fibrosis Health aspects Heart - parasitology Host-parasite relationships Identification and classification immune response Immunization Immunology Inflammation Inflammation - parasitology Medical Microbiology Mice Microbiology myocardium Myocardium - immunology Original Paper parasitemia Parasitemia - immunology parasites parasitology Physiological aspects Prevention T cells T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - physiology Th17 Cells - immunology Trypanosoma cruzi Trypanosoma cruzi - physiology
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