The A-repeat links ASF/SF2-dependent Xist RNA processing with random choice during X inactivation

The Xist noncoding RNA is a key component in silencing of one X chromosome in female mammalian cells as part of the process of dosage compensation. Now a previously described repeat element in Xist, the A-repeat, is shown to bind the splicing factor ASF/SF2, and it is further shown that normal Xist...

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Veröffentlicht in:	Nature structural & molecular biology 2010-08, Vol.17 (8), p.948-954
Hauptverfasser:	Royce-Tolland, Morgan E, Wutz, Anton, Tonks, Ian D, Kay, Graham F, Koyfman, Hannah R, Andersen, Angela A, Panning, Barbara, Talbot, Dale J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/103 631/337/1645 631/337/176/2016 631/337/384 Alleles Animals Base Sequence Biochemistry Biological Microscopy Biomedical and Life Sciences Chromosomes Chromosomes, Mammalian - metabolism Female Females Gene silencing HeLa Cells Histones - metabolism Humans Inactivation Life Sciences Male Mammals Membrane Biology Mice Models, Biological Molecular biology Molecular Sequence Data Nuclear Proteins - metabolism Nucleic Acid Conformation Physiological aspects Probability Protein Binding Protein Processing, Post-Translational Protein Structure Repetitive Sequences, Nucleic Acid - genetics Ribonucleic acid RNA RNA processing RNA Processing, Post-Transcriptional RNA, Long Noncoding RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Untranslated - chemistry RNA, Untranslated - genetics RNA-Binding Proteins - metabolism Sequence Deletion - genetics Serine-Arginine Splicing Factors Stochastic processes X chromosome X Chromosome Inactivation - genetics
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