Effects of Macromolecular Crowding on the Structure of a Protein Complex: A Small-Angle Scattering Study of Superoxide Dismutase

Macromolecular crowding can alter the structure and function of biological macromolecules. We used small-angle scattering to measure the effects of macromolecular crowding on the size of a protein complex, SOD (superoxide dismutase). Crowding was induced using 400 MW PEG (polyethylene glycol),TEG (t...

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Veröffentlicht in:	Biophysical journal 2015-02, Vol.108 (4), p.967-974
Hauptverfasser:	Rajapaksha, Ajith, Stanley, Christopher B., Todd, Brian A.
Format:	Artikel
Sprache:	eng
Schlagworte:	BASIC BIOLOGICAL SCIENCES Effects Enzymes Molecules Neutron Diffraction Polyethylene glycol Polyethylene Glycols - chemistry Protein Binding Protein Conformation Proteins Proteins and Nucleic Acids Scattering Scattering, Small Angle Superoxide Dismutase - chemistry
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