Prolyl Oligopeptidase Enhances α-Synuclein Dimerization via Direct Protein-Protein Interaction

Prolyl oligopeptidase (PREP) accelerates the aggregation of α-synuclein (aSyn), a key protein involved in development of Parkinson disease and other synucleinopathies. PREP inhibitors reduce aSyn aggregation, but the mechanism has remained unknown. We have now used protein-fragment complementation a...

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Veröffentlicht in:	The Journal of biological chemistry 2015-02, Vol.290 (8), p.5117-5126
Hauptverfasser:	Savolainen, Mari H., Yan, Xu, Myöhänen, Timo T., Huttunen, Henri J.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - metabolism Amino Acid Substitution Animals Autophagy Cell Line, Tumor Conformational Change Gene Expression Regulation, Enzymologic Inhibitor Mice Mutation, Missense Neurobiology Parkinson Disease Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson Disease - pathology Peptidase Proline - analogs & derivatives Proline - pharmacology Prolyl Oligopeptidases Protein Aggregation Protein Multimerization Protein Structure, Tertiary Protein-Protein Interaction Serine Endopeptidases - biosynthesis α-Synuclein (a-Synuclein)
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