Glutathione Suppresses Cerebral Infarct Volume and Cell Death after Ischemic Injury: Involvement of FOXO3 Inactivation and Bcl2 Expression

Ischemic stroke interrupts the flow of blood to the brain and subsequently results in cerebral infarction and neuronal cell death, leading to severe pathophysiology. Glutathione (GSH) is an antioxidant with cellular protective functions, including reactive oxygen species (ROS) scavenging in the brai...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oxidative medicine and cellular longevity 2015-01, Vol.2015 (2015), p.1-11
Hauptverfasser:	Lee, Jong Eun, Oh, Yumi, Park, Joohyun, Song, Juhyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Antioxidants - therapeutic use Apoptosis Biochemistry Blood-Brain Barrier - metabolism Brain - metabolism Brain - pathology Brain Ischemia - drug therapy Brain Ischemia - metabolism Brain Ischemia - pathology Cell death Cell Death - drug effects Cell Hypoxia Cell Line Colleges & universities Forkhead Box Protein O3 Forkhead Transcription Factors - metabolism Gene Expression Regulation Glutathione - pharmacology Glutathione - therapeutic use Ischemia Male Mice Neurons Oxidative Stress - drug effects Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Rodents Signal Transduction - drug effects Stroke Stroke (Disease) Thiols
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!