Increased susceptibility to methotrexate-induced toxicity in nonalcoholic steatohepatitis

Hepatic drug metabolizing enzymes and transporters play a crucial role in determining the fate of drugs, and alterations in liver function can place individuals at greater risk for adverse drug reactions (ADRs). We have shown that nonalcoholic steatohepatitis (NASH) leads to changes in the expressio...

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Veröffentlicht in:	Toxicological sciences 2014-11, Vol.142 (1), p.45-55
Hauptverfasser:	Hardwick, Rhiannon N, Clarke, John D, Lake, April D, Canet, Mark J, Anumol, Tarun, Street, Stephanie M, Merrell, Matthew D, Goedken, Michael J, Snyder, Shane A, Cherrington, Nathan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-Binding Cassette Transporters - metabolism Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - metabolism Disease Models, Animal Dose-Response Relationship, Drug Drug-Related Side Effects and Adverse Reactions - etiology Drug-Related Side Effects and Adverse Reactions - metabolism Feces - chemistry Kidney - drug effects Kidney - metabolism Liver - drug effects Liver - metabolism Male Methotrexate - blood Methotrexate - pharmacokinetics Methotrexate - toxicity Methotrexate - urine Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - metabolism Rats, Sprague-Dawley Tissue Distribution
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