Cytotoxicity of CD56-positive lymphocytes against autologous B-cell precursor acute lymphoblastic leukemia cells

Precursor B-lineage acute lymphoblastic leukemia (pre-B ALL) affects hematopoietic development and therefore is associated with immune deficiencies that can be further exacerbated by chemotherapy. It is unclear if and when monoclonal antibodies (mAbs) that stimulate antibody-mediated cellular cytoto...

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Veröffentlicht in:	Leukemia 2015-04, Vol.29 (4), p.788-797
Hauptverfasser:	Fei, F, Lim, M, George, A A, Kirzner, J, Lee, D, Seeger, R, Groffen, J, Abdel-Azim, H, Heisterkamp, N
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/106 13/31 631/154/51/1844 631/67/1990/283 631/67/580 692/699/67/1990/283/2125 Acute lymphoblastic leukemia Acute lymphocytic leukemia Antibodies, Monoclonal - biosynthesis Antigens Antineoplastic Agents - therapeutic use Autografts B-Lymphocytes - drug effects B-Lymphocytes - immunology B-Lymphocytes - pathology Bone marrow Bone Marrow Cells - drug effects Bone Marrow Cells - immunology Bone Marrow Cells - pathology Bone marrow transplantation Cancer Research Care and treatment CD3 antigen CD3 Complex - genetics CD3 Complex - metabolism CD56 antigen CD56 Antigen - genetics CD56 Antigen - metabolism Cell culture Cell mediated cytotoxicity Cell Proliferation - drug effects Cell therapy Cellular proteins Chemotherapy Child Coculture Techniques Critical Care Medicine Cytotoxicity Cytotoxicity, Immunologic Development and progression Diagnosis Drug therapy Effector cells Flow cytometry Gene Expression Genetic aspects Graft-versus-host reaction Health aspects Hematology Hemopoiesis Humans Intensive Interleukin 15 Interleukin-15 - pharmacology Internal Medicine K562 Cells Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Killer Cells, Natural - pathology Leukemia Lymphatic leukemia Lymphocytes Lymphocytes B Medicine Medicine & Public Health Monoclonal antibodies Oncology original-article Peripheral blood Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - immunology Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology Precursors Purging Remission Induction Toxicity Transplantation Transplants Transplants & implants
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