An assessment of correlation between serum asymmetric dimethylarginine and glycated haemoglobin in patients with type 2 diabetes mellitus
Studies that investigated an association between asymmetric dimethylarginine (ADMA) and glycated haemoglobin (HbA1c) in type 2 diabetes mellitus (T2DM) have given discordant results. The aim of this study was to determine and compare serum ADMA concentration in patients with T2DM and healthy control...
Gespeichert in:
| Veröffentlicht in: | Biomolecules & biomedicine 2014-02, Vol.14 (1), p.21-24 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 24 |
|---|---|
| container_issue | 1 |
| container_start_page | 21 |
| container_title | Biomolecules & biomedicine |
| container_volume | 14 |
| creator | Začiragić, Asja Huskić, Jasminko Mulabegović, Nedžad Avdagić, Nesina Valjevac, Amina Hasić, Sabaheta Jadrić, Radivoj |
| description | Studies that investigated an association between asymmetric dimethylarginine (ADMA) and glycated haemoglobin (HbA1c) in type 2 diabetes mellitus (T2DM) have given discordant results. The aim of this study was to determine and compare serum ADMA concentration in patients with T2DM and healthy controls, and to assess correlation between ADMA and HbA1c in patients with T2DM. Serum ADMA concentration was determined by ELISA method with the use of ADMA ® - ELISA kit (DLD Diagnostics, Hamburg, Germany) and HbA1c levels were determined by an immunoturbidimetric method in 60 patients with T2DM and 60 healthy individuals matched for age and sex. Results have shown that mean serum ADMA concentration was significantly higher in T2DM patients (1.54±0.06 μmol/L) compared to mean serum ADMA concentration (0.62±0.02 μmol/L; p |
| doi_str_mv | 10.17305/bjbms.2014.2291 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4333946</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>24579966</sourcerecordid><originalsourceid>FETCH-LOGICAL-c354t-4a67c80f3dd8615fc658b34898ebc7fb1cbc2d9290969f1f47081c35c927e7623</originalsourceid><addsrcrecordid>eNpVkctqHDEQRUVwiCe291kF_UBP9Gq1tDEY4zzAkE2yFpK6ekampR4kjU1_Qv7asp2YGAqqQLqnCg5CnyjZ0oGT_ou7c7FsGaFiy5im79CGKkE6oSg7QRumOO2I0vIUfSzljhCpuRIf0CkT_aC1lBv05yphWwqUEiFVvEzYLznDbGtYEnZQHwASLpCPsf1bY4Sag8djaMN-nW3ehRQSYJtGvJtXbyuMeG8hLrt5cSHhVocGa_CCH0Ld47oeALNGsI0OBUeY51CP5Ry9n-xc4OJvP0O_v978uv7e3f789uP66rbzvBe1E1YOXpGJj6OStJ-87JXjQmkFzg-To955NmqmiZZ6opMYiKIt6jUbYJCMn6HLF-7h6CKMvl2W7WwOOUSbV7PYYN6-pLA3u-XeCM65FrIByAvA56WUDNNrlhLzrMU8azFPWsyTlhb5_P_O18A_D_wR2yWPMA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>An assessment of correlation between serum asymmetric dimethylarginine and glycated haemoglobin in patients with type 2 diabetes mellitus</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Začiragić, Asja ; Huskić, Jasminko ; Mulabegović, Nedžad ; Avdagić, Nesina ; Valjevac, Amina ; Hasić, Sabaheta ; Jadrić, Radivoj</creator><creatorcontrib>Začiragić, Asja ; Huskić, Jasminko ; Mulabegović, Nedžad ; Avdagić, Nesina ; Valjevac, Amina ; Hasić, Sabaheta ; Jadrić, Radivoj</creatorcontrib><description>Studies that investigated an association between asymmetric dimethylarginine (ADMA) and glycated haemoglobin (HbA1c) in type 2 diabetes mellitus (T2DM) have given discordant results. The aim of this study was to determine and compare serum ADMA concentration in patients with T2DM and healthy controls, and to assess correlation between ADMA and HbA1c in patients with T2DM. Serum ADMA concentration was determined by ELISA method with the use of ADMA ® - ELISA kit (DLD Diagnostics, Hamburg, Germany) and HbA1c levels were determined by an immunoturbidimetric method in 60 patients with T2DM and 60 healthy individuals matched for age and sex. Results have shown that mean serum ADMA concentration was significantly higher in T2DM patients (1.54±0.06 μmol/L) compared to mean serum ADMA concentration (0.62±0.02 μmol/L; p<0.0001) in healthy subjects. A significant, positive, correlation between serum ADMA concentration and HbA1c levels was observed (r=0.494; p<0.01) in T2DM patients. Our results suggest that there is an association between endothelial dysfunction and glycaemic control in type 2 diabetes mellitus. Possible explanation for obtained results may be oxidative stress that is increased in conditions of hyperglycaemia and it also promotes endothelial dysfunction. Larger, longitudinal studies are required that will evaluate relation between metabolic abnormalities and increased ADMA levels in patients with type 2 diabetes mellitus.</description><identifier>ISSN: 2831-0896</identifier><identifier>ISSN: 1512-8601</identifier><identifier>EISSN: 1840-4812</identifier><identifier>EISSN: 2831-090X</identifier><identifier>DOI: 10.17305/bjbms.2014.2291</identifier><identifier>PMID: 24579966</identifier><language>eng</language><publisher>Bosnia and Herzegovina: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina</publisher><subject>Arginine - analogs & derivatives ; Arginine - blood ; Blood Glucose - analysis ; Case-Control Studies ; Diabetes Mellitus, Type 2 - blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Glycated Hemoglobin A - analysis ; Humans ; Hyperglycemia - drug therapy ; Male ; Middle Aged ; Nephelometry and Turbidimetry ; Oxidative Stress</subject><ispartof>Biomolecules & biomedicine, 2014-02, Vol.14 (1), p.21-24</ispartof><rights>Copyright: © Association of Basic Medical Sciences of FB&H. All rights reserved 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-4a67c80f3dd8615fc658b34898ebc7fb1cbc2d9290969f1f47081c35c927e7623</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333946/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333946/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24579966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Začiragić, Asja</creatorcontrib><creatorcontrib>Huskić, Jasminko</creatorcontrib><creatorcontrib>Mulabegović, Nedžad</creatorcontrib><creatorcontrib>Avdagić, Nesina</creatorcontrib><creatorcontrib>Valjevac, Amina</creatorcontrib><creatorcontrib>Hasić, Sabaheta</creatorcontrib><creatorcontrib>Jadrić, Radivoj</creatorcontrib><title>An assessment of correlation between serum asymmetric dimethylarginine and glycated haemoglobin in patients with type 2 diabetes mellitus</title><title>Biomolecules & biomedicine</title><addtitle>Bosn J Basic Med Sci</addtitle><description>Studies that investigated an association between asymmetric dimethylarginine (ADMA) and glycated haemoglobin (HbA1c) in type 2 diabetes mellitus (T2DM) have given discordant results. The aim of this study was to determine and compare serum ADMA concentration in patients with T2DM and healthy controls, and to assess correlation between ADMA and HbA1c in patients with T2DM. Serum ADMA concentration was determined by ELISA method with the use of ADMA ® - ELISA kit (DLD Diagnostics, Hamburg, Germany) and HbA1c levels were determined by an immunoturbidimetric method in 60 patients with T2DM and 60 healthy individuals matched for age and sex. Results have shown that mean serum ADMA concentration was significantly higher in T2DM patients (1.54±0.06 μmol/L) compared to mean serum ADMA concentration (0.62±0.02 μmol/L; p<0.0001) in healthy subjects. A significant, positive, correlation between serum ADMA concentration and HbA1c levels was observed (r=0.494; p<0.01) in T2DM patients. Our results suggest that there is an association between endothelial dysfunction and glycaemic control in type 2 diabetes mellitus. Possible explanation for obtained results may be oxidative stress that is increased in conditions of hyperglycaemia and it also promotes endothelial dysfunction. Larger, longitudinal studies are required that will evaluate relation between metabolic abnormalities and increased ADMA levels in patients with type 2 diabetes mellitus.</description><subject>Arginine - analogs & derivatives</subject><subject>Arginine - blood</subject><subject>Blood Glucose - analysis</subject><subject>Case-Control Studies</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Humans</subject><subject>Hyperglycemia - drug therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nephelometry and Turbidimetry</subject><subject>Oxidative Stress</subject><issn>2831-0896</issn><issn>1512-8601</issn><issn>1840-4812</issn><issn>2831-090X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkctqHDEQRUVwiCe291kF_UBP9Gq1tDEY4zzAkE2yFpK6ekampR4kjU1_Qv7asp2YGAqqQLqnCg5CnyjZ0oGT_ou7c7FsGaFiy5im79CGKkE6oSg7QRumOO2I0vIUfSzljhCpuRIf0CkT_aC1lBv05yphWwqUEiFVvEzYLznDbGtYEnZQHwASLpCPsf1bY4Sag8djaMN-nW3ehRQSYJtGvJtXbyuMeG8hLrt5cSHhVocGa_CCH0Ld47oeALNGsI0OBUeY51CP5Ry9n-xc4OJvP0O_v978uv7e3f789uP66rbzvBe1E1YOXpGJj6OStJ-87JXjQmkFzg-To955NmqmiZZ6opMYiKIt6jUbYJCMn6HLF-7h6CKMvl2W7WwOOUSbV7PYYN6-pLA3u-XeCM65FrIByAvA56WUDNNrlhLzrMU8azFPWsyTlhb5_P_O18A_D_wR2yWPMA</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Začiragić, Asja</creator><creator>Huskić, Jasminko</creator><creator>Mulabegović, Nedžad</creator><creator>Avdagić, Nesina</creator><creator>Valjevac, Amina</creator><creator>Hasić, Sabaheta</creator><creator>Jadrić, Radivoj</creator><general>Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20140201</creationdate><title>An assessment of correlation between serum asymmetric dimethylarginine and glycated haemoglobin in patients with type 2 diabetes mellitus</title><author>Začiragić, Asja ; Huskić, Jasminko ; Mulabegović, Nedžad ; Avdagić, Nesina ; Valjevac, Amina ; Hasić, Sabaheta ; Jadrić, Radivoj</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-4a67c80f3dd8615fc658b34898ebc7fb1cbc2d9290969f1f47081c35c927e7623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Arginine - analogs & derivatives</topic><topic>Arginine - blood</topic><topic>Blood Glucose - analysis</topic><topic>Case-Control Studies</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Humans</topic><topic>Hyperglycemia - drug therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nephelometry and Turbidimetry</topic><topic>Oxidative Stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Začiragić, Asja</creatorcontrib><creatorcontrib>Huskić, Jasminko</creatorcontrib><creatorcontrib>Mulabegović, Nedžad</creatorcontrib><creatorcontrib>Avdagić, Nesina</creatorcontrib><creatorcontrib>Valjevac, Amina</creatorcontrib><creatorcontrib>Hasić, Sabaheta</creatorcontrib><creatorcontrib>Jadrić, Radivoj</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biomolecules & biomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Začiragić, Asja</au><au>Huskić, Jasminko</au><au>Mulabegović, Nedžad</au><au>Avdagić, Nesina</au><au>Valjevac, Amina</au><au>Hasić, Sabaheta</au><au>Jadrić, Radivoj</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An assessment of correlation between serum asymmetric dimethylarginine and glycated haemoglobin in patients with type 2 diabetes mellitus</atitle><jtitle>Biomolecules & biomedicine</jtitle><addtitle>Bosn J Basic Med Sci</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>14</volume><issue>1</issue><spage>21</spage><epage>24</epage><pages>21-24</pages><issn>2831-0896</issn><issn>1512-8601</issn><eissn>1840-4812</eissn><eissn>2831-090X</eissn><abstract>Studies that investigated an association between asymmetric dimethylarginine (ADMA) and glycated haemoglobin (HbA1c) in type 2 diabetes mellitus (T2DM) have given discordant results. The aim of this study was to determine and compare serum ADMA concentration in patients with T2DM and healthy controls, and to assess correlation between ADMA and HbA1c in patients with T2DM. Serum ADMA concentration was determined by ELISA method with the use of ADMA ® - ELISA kit (DLD Diagnostics, Hamburg, Germany) and HbA1c levels were determined by an immunoturbidimetric method in 60 patients with T2DM and 60 healthy individuals matched for age and sex. Results have shown that mean serum ADMA concentration was significantly higher in T2DM patients (1.54±0.06 μmol/L) compared to mean serum ADMA concentration (0.62±0.02 μmol/L; p<0.0001) in healthy subjects. A significant, positive, correlation between serum ADMA concentration and HbA1c levels was observed (r=0.494; p<0.01) in T2DM patients. Our results suggest that there is an association between endothelial dysfunction and glycaemic control in type 2 diabetes mellitus. Possible explanation for obtained results may be oxidative stress that is increased in conditions of hyperglycaemia and it also promotes endothelial dysfunction. Larger, longitudinal studies are required that will evaluate relation between metabolic abnormalities and increased ADMA levels in patients with type 2 diabetes mellitus.</abstract><cop>Bosnia and Herzegovina</cop><pub>Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina</pub><pmid>24579966</pmid><doi>10.17305/bjbms.2014.2291</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2831-0896 |
| ispartof | Biomolecules & biomedicine, 2014-02, Vol.14 (1), p.21-24 |
| issn | 2831-0896 1512-8601 1840-4812 2831-090X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4333946 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Arginine - analogs & derivatives Arginine - blood Blood Glucose - analysis Case-Control Studies Diabetes Mellitus, Type 2 - blood Enzyme-Linked Immunosorbent Assay Female Glycated Hemoglobin A - analysis Humans Hyperglycemia - drug therapy Male Middle Aged Nephelometry and Turbidimetry Oxidative Stress |
| title | An assessment of correlation between serum asymmetric dimethylarginine and glycated haemoglobin in patients with type 2 diabetes mellitus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T02%3A07%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20assessment%20of%20correlation%20between%20serum%20asymmetric%20dimethylarginine%20and%20glycated%20haemoglobin%20in%20patients%20with%20type%202%20diabetes%20mellitus&rft.jtitle=Biomolecules%20&%20biomedicine&rft.au=Za%C4%8Diragi%C4%87,%20Asja&rft.date=2014-02-01&rft.volume=14&rft.issue=1&rft.spage=21&rft.epage=24&rft.pages=21-24&rft.issn=2831-0896&rft.eissn=1840-4812&rft_id=info:doi/10.17305/bjbms.2014.2291&rft_dat=%3Cpubmed_cross%3E24579966%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/24579966&rfr_iscdi=true |