LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4
Long non-coding-RNAs are emerging as important regulators of cellular functions but little is known on their role in human immune system. Here we investigated long intergenic non-coding-RNAs (lincRNAs) in thirteen T and B lymphocyte subsets by RNA-seq analysis and de novo transcriptome reconstructio...
Gespeichert in:
| Veröffentlicht in: | Nature immunology 2015-01, Vol.16 (3), p.318-325 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 325 |
|---|---|
| container_issue | 3 |
| container_start_page | 318 |
| container_title | Nature immunology |
| container_volume | 16 |
| creator | Ranzani, Valeria Rossetti, Grazisa Panzeri, Ilaria Arrigoni, Alberto Bonnal, Raoul JP Curti, Serena Gruarin, Paola Provasi, Elena Sugliano, Elisa Marconi, Maurizio De Francesco, Raffaele Geginat, Jens Bodega, Beatrice Abrignani, Sergio Pagani, Massimiliano |
| description | Long non-coding-RNAs are emerging as important regulators of cellular functions but little is known on their role in human immune system. Here we investigated long intergenic non-coding-RNAs (lincRNAs) in thirteen T and B lymphocyte subsets by RNA-seq analysis and
de novo
transcriptome reconstruction. Over five hundred new lincRNAs were identified and lincRNAs signatures were described. Expression of linc-MAF-4, a chromatin-associated T
H
1-specific lincRNA, was inversely correlated with MAF, a T
H
2-associated transcription factor. Linc-MAF-4 down-regulation skewed T cell differentiation toward T
H
2. We identified a long-distance interaction between
linc-MAF-4
and
MAF
genomic regions, where linc-MAF-4 associates with LSD1 and EZH2, suggesting linc-MAF-4 regulated
MAF
transcription by recruitment of chromatin modifiers. Our results demonstrate a key role of lincRNAs in T lymphocyte differentiation. |
| doi_str_mv | 10.1038/ni.3093 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmedcentral</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4333215</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>pubmedcentral_primary_oai_pubmedcentral_nih_gov_4333215</sourcerecordid><originalsourceid>FETCH-pubmedcentral_primary_oai_pubmedcentral_nih_gov_43332153</originalsourceid><addsrcrecordid>eNqljM1KxDAUhYMozoyKr3BfoGN-2tpuhEEcZqEuhtmHTJo2V9KkJK3Qt7egCK5dHM6Bj_MRcs_ollFRPXjcClqLC7JmBa8zXrPy8nfTakU2KX1QyvLHMr8mK16UnFW8XJPmFb0-vu_AKd8krQYD6MFOvfLg5n6wQc-jSWCxs27JmCCabnJqxOAhtHACbZyDBtvWRONH_CbnGdxizt52-yy_JVetcsnc_fQNedq_nJ4P2TCde9Po5RaVk0PEXsVZBoXyL_FoZRc-ZS6E4KwQ_xZ8AYgsY18</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4</title><source>Nature</source><source>Alma/SFX Local Collection</source><creator>Ranzani, Valeria ; Rossetti, Grazisa ; Panzeri, Ilaria ; Arrigoni, Alberto ; Bonnal, Raoul JP ; Curti, Serena ; Gruarin, Paola ; Provasi, Elena ; Sugliano, Elisa ; Marconi, Maurizio ; De Francesco, Raffaele ; Geginat, Jens ; Bodega, Beatrice ; Abrignani, Sergio ; Pagani, Massimiliano</creator><creatorcontrib>Ranzani, Valeria ; Rossetti, Grazisa ; Panzeri, Ilaria ; Arrigoni, Alberto ; Bonnal, Raoul JP ; Curti, Serena ; Gruarin, Paola ; Provasi, Elena ; Sugliano, Elisa ; Marconi, Maurizio ; De Francesco, Raffaele ; Geginat, Jens ; Bodega, Beatrice ; Abrignani, Sergio ; Pagani, Massimiliano</creatorcontrib><description>Long non-coding-RNAs are emerging as important regulators of cellular functions but little is known on their role in human immune system. Here we investigated long intergenic non-coding-RNAs (lincRNAs) in thirteen T and B lymphocyte subsets by RNA-seq analysis and
de novo
transcriptome reconstruction. Over five hundred new lincRNAs were identified and lincRNAs signatures were described. Expression of linc-MAF-4, a chromatin-associated T
H
1-specific lincRNA, was inversely correlated with MAF, a T
H
2-associated transcription factor. Linc-MAF-4 down-regulation skewed T cell differentiation toward T
H
2. We identified a long-distance interaction between
linc-MAF-4
and
MAF
genomic regions, where linc-MAF-4 associates with LSD1 and EZH2, suggesting linc-MAF-4 regulated
MAF
transcription by recruitment of chromatin modifiers. Our results demonstrate a key role of lincRNAs in T lymphocyte differentiation.</description><identifier>ISSN: 1529-2908</identifier><identifier>EISSN: 1529-2916</identifier><identifier>DOI: 10.1038/ni.3093</identifier><identifier>PMID: 25621826</identifier><language>eng</language><ispartof>Nature immunology, 2015-01, Vol.16 (3), p.318-325</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids></links><search><creatorcontrib>Ranzani, Valeria</creatorcontrib><creatorcontrib>Rossetti, Grazisa</creatorcontrib><creatorcontrib>Panzeri, Ilaria</creatorcontrib><creatorcontrib>Arrigoni, Alberto</creatorcontrib><creatorcontrib>Bonnal, Raoul JP</creatorcontrib><creatorcontrib>Curti, Serena</creatorcontrib><creatorcontrib>Gruarin, Paola</creatorcontrib><creatorcontrib>Provasi, Elena</creatorcontrib><creatorcontrib>Sugliano, Elisa</creatorcontrib><creatorcontrib>Marconi, Maurizio</creatorcontrib><creatorcontrib>De Francesco, Raffaele</creatorcontrib><creatorcontrib>Geginat, Jens</creatorcontrib><creatorcontrib>Bodega, Beatrice</creatorcontrib><creatorcontrib>Abrignani, Sergio</creatorcontrib><creatorcontrib>Pagani, Massimiliano</creatorcontrib><title>LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4</title><title>Nature immunology</title><description>Long non-coding-RNAs are emerging as important regulators of cellular functions but little is known on their role in human immune system. Here we investigated long intergenic non-coding-RNAs (lincRNAs) in thirteen T and B lymphocyte subsets by RNA-seq analysis and
de novo
transcriptome reconstruction. Over five hundred new lincRNAs were identified and lincRNAs signatures were described. Expression of linc-MAF-4, a chromatin-associated T
H
1-specific lincRNA, was inversely correlated with MAF, a T
H
2-associated transcription factor. Linc-MAF-4 down-regulation skewed T cell differentiation toward T
H
2. We identified a long-distance interaction between
linc-MAF-4
and
MAF
genomic regions, where linc-MAF-4 associates with LSD1 and EZH2, suggesting linc-MAF-4 regulated
MAF
transcription by recruitment of chromatin modifiers. Our results demonstrate a key role of lincRNAs in T lymphocyte differentiation.</description><issn>1529-2908</issn><issn>1529-2916</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqljM1KxDAUhYMozoyKr3BfoGN-2tpuhEEcZqEuhtmHTJo2V9KkJK3Qt7egCK5dHM6Bj_MRcs_ollFRPXjcClqLC7JmBa8zXrPy8nfTakU2KX1QyvLHMr8mK16UnFW8XJPmFb0-vu_AKd8krQYD6MFOvfLg5n6wQc-jSWCxs27JmCCabnJqxOAhtHACbZyDBtvWRONH_CbnGdxizt52-yy_JVetcsnc_fQNedq_nJ4P2TCde9Po5RaVk0PEXsVZBoXyL_FoZRc-ZS6E4KwQ_xZ8AYgsY18</recordid><startdate>20150126</startdate><enddate>20150126</enddate><creator>Ranzani, Valeria</creator><creator>Rossetti, Grazisa</creator><creator>Panzeri, Ilaria</creator><creator>Arrigoni, Alberto</creator><creator>Bonnal, Raoul JP</creator><creator>Curti, Serena</creator><creator>Gruarin, Paola</creator><creator>Provasi, Elena</creator><creator>Sugliano, Elisa</creator><creator>Marconi, Maurizio</creator><creator>De Francesco, Raffaele</creator><creator>Geginat, Jens</creator><creator>Bodega, Beatrice</creator><creator>Abrignani, Sergio</creator><creator>Pagani, Massimiliano</creator><scope>5PM</scope></search><sort><creationdate>20150126</creationdate><title>LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4</title><author>Ranzani, Valeria ; Rossetti, Grazisa ; Panzeri, Ilaria ; Arrigoni, Alberto ; Bonnal, Raoul JP ; Curti, Serena ; Gruarin, Paola ; Provasi, Elena ; Sugliano, Elisa ; Marconi, Maurizio ; De Francesco, Raffaele ; Geginat, Jens ; Bodega, Beatrice ; Abrignani, Sergio ; Pagani, Massimiliano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmedcentral_primary_oai_pubmedcentral_nih_gov_43332153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ranzani, Valeria</creatorcontrib><creatorcontrib>Rossetti, Grazisa</creatorcontrib><creatorcontrib>Panzeri, Ilaria</creatorcontrib><creatorcontrib>Arrigoni, Alberto</creatorcontrib><creatorcontrib>Bonnal, Raoul JP</creatorcontrib><creatorcontrib>Curti, Serena</creatorcontrib><creatorcontrib>Gruarin, Paola</creatorcontrib><creatorcontrib>Provasi, Elena</creatorcontrib><creatorcontrib>Sugliano, Elisa</creatorcontrib><creatorcontrib>Marconi, Maurizio</creatorcontrib><creatorcontrib>De Francesco, Raffaele</creatorcontrib><creatorcontrib>Geginat, Jens</creatorcontrib><creatorcontrib>Bodega, Beatrice</creatorcontrib><creatorcontrib>Abrignani, Sergio</creatorcontrib><creatorcontrib>Pagani, Massimiliano</creatorcontrib><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ranzani, Valeria</au><au>Rossetti, Grazisa</au><au>Panzeri, Ilaria</au><au>Arrigoni, Alberto</au><au>Bonnal, Raoul JP</au><au>Curti, Serena</au><au>Gruarin, Paola</au><au>Provasi, Elena</au><au>Sugliano, Elisa</au><au>Marconi, Maurizio</au><au>De Francesco, Raffaele</au><au>Geginat, Jens</au><au>Bodega, Beatrice</au><au>Abrignani, Sergio</au><au>Pagani, Massimiliano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4</atitle><jtitle>Nature immunology</jtitle><date>2015-01-26</date><risdate>2015</risdate><volume>16</volume><issue>3</issue><spage>318</spage><epage>325</epage><pages>318-325</pages><issn>1529-2908</issn><eissn>1529-2916</eissn><abstract>Long non-coding-RNAs are emerging as important regulators of cellular functions but little is known on their role in human immune system. Here we investigated long intergenic non-coding-RNAs (lincRNAs) in thirteen T and B lymphocyte subsets by RNA-seq analysis and
de novo
transcriptome reconstruction. Over five hundred new lincRNAs were identified and lincRNAs signatures were described. Expression of linc-MAF-4, a chromatin-associated T
H
1-specific lincRNA, was inversely correlated with MAF, a T
H
2-associated transcription factor. Linc-MAF-4 down-regulation skewed T cell differentiation toward T
H
2. We identified a long-distance interaction between
linc-MAF-4
and
MAF
genomic regions, where linc-MAF-4 associates with LSD1 and EZH2, suggesting linc-MAF-4 regulated
MAF
transcription by recruitment of chromatin modifiers. Our results demonstrate a key role of lincRNAs in T lymphocyte differentiation.</abstract><pmid>25621826</pmid><doi>10.1038/ni.3093</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1529-2908 |
| ispartof | Nature immunology, 2015-01, Vol.16 (3), p.318-325 |
| issn | 1529-2908 1529-2916 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4333215 |
| source | Nature; Alma/SFX Local Collection |
| title | LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T11%3A58%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmedcentral&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=LincRNA%20landscape%20in%20human%20lymphocytes%20highlights%20regulation%20of%20T%20cell%20differentiation%20by%20linc-MAF-4&rft.jtitle=Nature%20immunology&rft.au=Ranzani,%20Valeria&rft.date=2015-01-26&rft.volume=16&rft.issue=3&rft.spage=318&rft.epage=325&rft.pages=318-325&rft.issn=1529-2908&rft.eissn=1529-2916&rft_id=info:doi/10.1038/ni.3093&rft_dat=%3Cpubmedcentral%3Epubmedcentral_primary_oai_pubmedcentral_nih_gov_4333215%3C/pubmedcentral%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/25621826&rfr_iscdi=true |