Protection of Malian children from clinical malaria is associated with recognition of multiple antigens
Naturally acquired immunity to clinical malaria is thought to be mainly antibody-mediated, but reports on antigen targets are contradictory. Recognition of multiple antigens may be crucial for protection. In this study, the magnitude of antibody responses and their temporal stability was assessed fo...
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Veröffentlicht in: | Malaria journal 2015-02, Vol.14 (1), p.56-56, Article 56 |
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creator | Daou, Modibo Kouriba, Bourèma Ouédraogo, Nicolas Diarra, Issa Arama, Charles Keita, Yamoussa Sissoko, Sibiri Ouologuem, Boucary Arama, Seydou Bousema, Teun Doumbo, Ogobara K Sauerwein, Robert W Scholzen, Anja |
description | Naturally acquired immunity to clinical malaria is thought to be mainly antibody-mediated, but reports on antigen targets are contradictory. Recognition of multiple antigens may be crucial for protection. In this study, the magnitude of antibody responses and their temporal stability was assessed for a panel of malaria antigens in relation to protection against clinical Plasmodium falciparum malaria.
Malian children aged two to 14 years were enrolled in a longitudinal study and followed up by passive and active case detection for seven months. Plasma was collected at enrolment and at the beginning, in the middle and after the end of the transmission season. Antibody titres to the P. falciparum-antigens apical membrane protein (AMA)-1, merozoite surface protein (MSP)-1₁₉, MSP-3, glutamine-rich protein (GLURP-R0) and circumsporozoite antigen (CSP) were assessed by enzyme-linked immunosorbent assay (ELISA) for 99 children with plasma available at all time points. Parasite carriage was determined by microscopy and nested PCR.
Antibody titres to all antigens, except MSP-1₁₉, and the number of antigens recognized increased with age. After malaria exposure, antibody titres increased in children that had low titres at baseline, but decreased in those with high baseline responses. No significant differences were found between antibody titers for individual antigens between children remaining symptomatic or asymptomatic after exposure, after adjustment for age. Instead, children remaining asymptomatic following parasite exposure had a broader repertoire of antigen recognition.
The present study provides immune-epidemiological evidence from a limited cohort of Malian children that strong recognition of multiple antigens, rather than antibody titres for individual antigens, is associated with protection from clinical malaria. |
doi_str_mv | 10.1186/s12936-015-0567-9 |
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Malian children aged two to 14 years were enrolled in a longitudinal study and followed up by passive and active case detection for seven months. Plasma was collected at enrolment and at the beginning, in the middle and after the end of the transmission season. Antibody titres to the P. falciparum-antigens apical membrane protein (AMA)-1, merozoite surface protein (MSP)-1₁₉, MSP-3, glutamine-rich protein (GLURP-R0) and circumsporozoite antigen (CSP) were assessed by enzyme-linked immunosorbent assay (ELISA) for 99 children with plasma available at all time points. Parasite carriage was determined by microscopy and nested PCR.
Antibody titres to all antigens, except MSP-1₁₉, and the number of antigens recognized increased with age. After malaria exposure, antibody titres increased in children that had low titres at baseline, but decreased in those with high baseline responses. No significant differences were found between antibody titers for individual antigens between children remaining symptomatic or asymptomatic after exposure, after adjustment for age. Instead, children remaining asymptomatic following parasite exposure had a broader repertoire of antigen recognition.
The present study provides immune-epidemiological evidence from a limited cohort of Malian children that strong recognition of multiple antigens, rather than antibody titres for individual antigens, is associated with protection from clinical malaria.</description><identifier>ISSN: 1475-2875</identifier><identifier>EISSN: 1475-2875</identifier><identifier>DOI: 10.1186/s12936-015-0567-9</identifier><identifier>PMID: 25653026</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adolescent ; Antibodies, Protozoan - blood ; Antigens, Protozoan - immunology ; Child ; Child, Preschool ; Humans ; Longitudinal Studies ; Malaria, Falciparum - epidemiology ; Malaria, Falciparum - immunology ; Mali - epidemiology ; Seasons</subject><ispartof>Malaria journal, 2015-02, Vol.14 (1), p.56-56, Article 56</ispartof><rights>Daou et al.; licensee BioMed Central. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b460t-ce8ca9300e58cfc851694deb043bf1f0cffffc7a78a08f19c07815308f7a1d743</citedby><cites>FETCH-LOGICAL-b460t-ce8ca9300e58cfc851694deb043bf1f0cffffc7a78a08f19c07815308f7a1d743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332451/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332451/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25653026$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Daou, Modibo</creatorcontrib><creatorcontrib>Kouriba, Bourèma</creatorcontrib><creatorcontrib>Ouédraogo, Nicolas</creatorcontrib><creatorcontrib>Diarra, Issa</creatorcontrib><creatorcontrib>Arama, Charles</creatorcontrib><creatorcontrib>Keita, Yamoussa</creatorcontrib><creatorcontrib>Sissoko, Sibiri</creatorcontrib><creatorcontrib>Ouologuem, Boucary</creatorcontrib><creatorcontrib>Arama, Seydou</creatorcontrib><creatorcontrib>Bousema, Teun</creatorcontrib><creatorcontrib>Doumbo, Ogobara K</creatorcontrib><creatorcontrib>Sauerwein, Robert W</creatorcontrib><creatorcontrib>Scholzen, Anja</creatorcontrib><title>Protection of Malian children from clinical malaria is associated with recognition of multiple antigens</title><title>Malaria journal</title><addtitle>Malar J</addtitle><description>Naturally acquired immunity to clinical malaria is thought to be mainly antibody-mediated, but reports on antigen targets are contradictory. Recognition of multiple antigens may be crucial for protection. In this study, the magnitude of antibody responses and their temporal stability was assessed for a panel of malaria antigens in relation to protection against clinical Plasmodium falciparum malaria.
Malian children aged two to 14 years were enrolled in a longitudinal study and followed up by passive and active case detection for seven months. Plasma was collected at enrolment and at the beginning, in the middle and after the end of the transmission season. Antibody titres to the P. falciparum-antigens apical membrane protein (AMA)-1, merozoite surface protein (MSP)-1₁₉, MSP-3, glutamine-rich protein (GLURP-R0) and circumsporozoite antigen (CSP) were assessed by enzyme-linked immunosorbent assay (ELISA) for 99 children with plasma available at all time points. Parasite carriage was determined by microscopy and nested PCR.
Antibody titres to all antigens, except MSP-1₁₉, and the number of antigens recognized increased with age. After malaria exposure, antibody titres increased in children that had low titres at baseline, but decreased in those with high baseline responses. No significant differences were found between antibody titers for individual antigens between children remaining symptomatic or asymptomatic after exposure, after adjustment for age. Instead, children remaining asymptomatic following parasite exposure had a broader repertoire of antigen recognition.
The present study provides immune-epidemiological evidence from a limited cohort of Malian children that strong recognition of multiple antigens, rather than antibody titres for individual antigens, is associated with protection from clinical malaria.</description><subject>Adolescent</subject><subject>Antibodies, Protozoan - blood</subject><subject>Antigens, Protozoan - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Malaria, Falciparum - epidemiology</subject><subject>Malaria, Falciparum - immunology</subject><subject>Mali - epidemiology</subject><subject>Seasons</subject><issn>1475-2875</issn><issn>1475-2875</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAQhi0EoqXwA7ggH7mk2HH8kQsSavmSiuAAZ2vi2LuDHHuxvUX8e7LatmolmItHGvt5PXoIecnZOedGvam8H4XqGJcdk0p34yNyygctu95o-fhef0Ke1fqTMa6N7p-Sk14qKVivTsnmW8nNu4Y50RzoF4gIibotxrn4REPJC3UREzqIdIEIBYFipVBrdgjNz_Q3ti0t3uVNwlvOso8Nd9FTSA03PtXn5EmAWP2Lm_OM_Pjw_vvFp-7q68fPF--uumlQrHXOGwejYMxL44IzkqtxmP3EBjEFHpgLazkN2gAzgY-OacPXVUzQwGc9iDPy9sjd7afFz86nViDaXcEFyh-bAe3DScKt3eRrOwjRD5KvgMsjYML8H8DDicuLPYqwqwh7EGHHFfP65h8l_9r72uyC1fkYIfm8r5YrPSgzCn1I5MerruRaiw93YZzZg-d_4l_dX_Puxa1Y8Rdaj6ey</recordid><startdate>20150205</startdate><enddate>20150205</enddate><creator>Daou, Modibo</creator><creator>Kouriba, Bourèma</creator><creator>Ouédraogo, Nicolas</creator><creator>Diarra, Issa</creator><creator>Arama, Charles</creator><creator>Keita, Yamoussa</creator><creator>Sissoko, Sibiri</creator><creator>Ouologuem, Boucary</creator><creator>Arama, Seydou</creator><creator>Bousema, Teun</creator><creator>Doumbo, Ogobara K</creator><creator>Sauerwein, Robert W</creator><creator>Scholzen, Anja</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150205</creationdate><title>Protection of Malian children from clinical malaria is associated with recognition of multiple antigens</title><author>Daou, Modibo ; Kouriba, Bourèma ; Ouédraogo, Nicolas ; Diarra, Issa ; Arama, Charles ; Keita, Yamoussa ; Sissoko, Sibiri ; Ouologuem, Boucary ; Arama, Seydou ; Bousema, Teun ; Doumbo, Ogobara K ; Sauerwein, Robert W ; Scholzen, Anja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b460t-ce8ca9300e58cfc851694deb043bf1f0cffffc7a78a08f19c07815308f7a1d743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Antibodies, Protozoan - blood</topic><topic>Antigens, Protozoan - immunology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Malaria, Falciparum - epidemiology</topic><topic>Malaria, Falciparum - immunology</topic><topic>Mali - epidemiology</topic><topic>Seasons</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Daou, Modibo</creatorcontrib><creatorcontrib>Kouriba, Bourèma</creatorcontrib><creatorcontrib>Ouédraogo, Nicolas</creatorcontrib><creatorcontrib>Diarra, Issa</creatorcontrib><creatorcontrib>Arama, Charles</creatorcontrib><creatorcontrib>Keita, Yamoussa</creatorcontrib><creatorcontrib>Sissoko, Sibiri</creatorcontrib><creatorcontrib>Ouologuem, Boucary</creatorcontrib><creatorcontrib>Arama, Seydou</creatorcontrib><creatorcontrib>Bousema, Teun</creatorcontrib><creatorcontrib>Doumbo, Ogobara K</creatorcontrib><creatorcontrib>Sauerwein, Robert W</creatorcontrib><creatorcontrib>Scholzen, Anja</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Malaria journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Daou, Modibo</au><au>Kouriba, Bourèma</au><au>Ouédraogo, Nicolas</au><au>Diarra, Issa</au><au>Arama, Charles</au><au>Keita, Yamoussa</au><au>Sissoko, Sibiri</au><au>Ouologuem, Boucary</au><au>Arama, Seydou</au><au>Bousema, Teun</au><au>Doumbo, Ogobara K</au><au>Sauerwein, Robert W</au><au>Scholzen, Anja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protection of Malian children from clinical malaria is associated with recognition of multiple antigens</atitle><jtitle>Malaria journal</jtitle><addtitle>Malar J</addtitle><date>2015-02-05</date><risdate>2015</risdate><volume>14</volume><issue>1</issue><spage>56</spage><epage>56</epage><pages>56-56</pages><artnum>56</artnum><issn>1475-2875</issn><eissn>1475-2875</eissn><abstract>Naturally acquired immunity to clinical malaria is thought to be mainly antibody-mediated, but reports on antigen targets are contradictory. Recognition of multiple antigens may be crucial for protection. In this study, the magnitude of antibody responses and their temporal stability was assessed for a panel of malaria antigens in relation to protection against clinical Plasmodium falciparum malaria.
Malian children aged two to 14 years were enrolled in a longitudinal study and followed up by passive and active case detection for seven months. Plasma was collected at enrolment and at the beginning, in the middle and after the end of the transmission season. Antibody titres to the P. falciparum-antigens apical membrane protein (AMA)-1, merozoite surface protein (MSP)-1₁₉, MSP-3, glutamine-rich protein (GLURP-R0) and circumsporozoite antigen (CSP) were assessed by enzyme-linked immunosorbent assay (ELISA) for 99 children with plasma available at all time points. Parasite carriage was determined by microscopy and nested PCR.
Antibody titres to all antigens, except MSP-1₁₉, and the number of antigens recognized increased with age. After malaria exposure, antibody titres increased in children that had low titres at baseline, but decreased in those with high baseline responses. No significant differences were found between antibody titers for individual antigens between children remaining symptomatic or asymptomatic after exposure, after adjustment for age. Instead, children remaining asymptomatic following parasite exposure had a broader repertoire of antigen recognition.
The present study provides immune-epidemiological evidence from a limited cohort of Malian children that strong recognition of multiple antigens, rather than antibody titres for individual antigens, is associated with protection from clinical malaria.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>25653026</pmid><doi>10.1186/s12936-015-0567-9</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Antibodies, Protozoan - blood Antigens, Protozoan - immunology Child Child, Preschool Humans Longitudinal Studies Malaria, Falciparum - epidemiology Malaria, Falciparum - immunology Mali - epidemiology Seasons |
title | Protection of Malian children from clinical malaria is associated with recognition of multiple antigens |
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