Association of stressful life events with accelerated bone loss in older men: the osteoporotic fractures in men (MrOS) study
Summary Prior studies suggest an association between stressful life events and fractures that may be mediated by BMD. In the current study, risk of accelerated hip BMD loss was higher in older men with any type of stressful life event and increased with the number of types of stressful life events....
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| Veröffentlicht in: | Osteoporosis international 2014-12, Vol.25 (12), p.2833-2839 |
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| description | Summary
Prior studies suggest an association between stressful life events and fractures that may be mediated by BMD. In the current study, risk of accelerated hip BMD loss was higher in older men with any type of stressful life event and increased with the number of types of stressful life events.
Introduction
Prior studies suggest that stressful life events may increase adverse health outcomes, including falls and possibly fractures. The current study builds on these findings and examines whether stressful life events are associated with increased bone loss.
Methods
Four thousand three hundred eighty-eight men aged ≥65 years in the Osteoporotic Fractures in Men study completed total hip bone mineral density (BMD) measures at baseline and visit 2, approximately 4.6 years later, and self-reported stressful life events data mid-way between baseline and visit 2, and at visit 2. We used linear regression to model the association of stressful life events with concurrent annualized total hip BMD loss, and log binomial regression or Poisson regression to model risk of concurrent accelerated BMD loss (>1 SD more than mean annualized change).
Results
Men (75.3 %) reported ≥1 type of stressful life event, including 43.3 % with ≥2 types of stressful life events. Mean annualized BMD loss was −0.36 % (SD 0.88), and 13.9 % of men were categorized with accelerated BMD loss (about 5.7 % or more total loss). Rate of annualized BMD loss increased with the number of types of stressful life events after adjustment for age (
p
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| doi_str_mv | 10.1007/s00198-014-2853-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4331181</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3483189591</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-6f77b34f757f7d3913da1d439cf412339d6afd766c321d96d045faafe49401403</originalsourceid><addsrcrecordid>eNp1kUFrFTEUhYMo9ln9AW4k4KYuRnMnmcnERaEUW4VKFyq4C3nJTV_KvMkzyVQK_ngzvFqq4CqL-51zc88h5CWwt8CYfJcZAzU0DETTDh1vhkdkBYLzplV995ismOKyUQK-H5BnOV-zqlFKPiUHbQe9Ei2syK-TnKMNpoQ40ehpLglz9vNIx-CR4g1OJdOfoWyosRZHTKago-s4IR1jzjRU2egw0S1O72nZII25YNzFFEuw1Cdjy1w9F7Ai9Ohzuvzypu6Z3e1z8sSbMeOLu_eQfDv78PX0Y3Nxef7p9OSisZ1gpem9lGsuvOykl44r4M6AE1xZL6DlXLneeCf73vIWnOodE503xqNQombD-CE53vvu5vUWna03JTPqXQpbk251NEH_PZnCRl_FG12zBBigGhzdGaT4Y8Zc9DbkmsZoJoxz1tC3LetByWXX63_Q6zinqZ63UKwexHlXKdhTNtUQE_r7zwDTS7d6362u_9dLt3qomlcPr7hX_CmzAu0eyHU0XWF6sPq_rr8BGIqwwA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1620540335</pqid></control><display><type>article</type><title>Association of stressful life events with accelerated bone loss in older men: the osteoporotic fractures in men (MrOS) study</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Fink, H. A. ; Kuskowski, M. A. ; Cauley, J. A. ; Taylor, B. C. ; Schousboe, J. T. ; Cawthon, P. M. ; Ensrud, K. E.</creator><creatorcontrib>Fink, H. A. ; Kuskowski, M. A. ; Cauley, J. A. ; Taylor, B. C. ; Schousboe, J. T. ; Cawthon, P. M. ; Ensrud, K. E. ; Osteoporotic Fractures in Men (MrOS) Study Group ; For the Osteoporotic Fractures in Men (MrOS) Study Group</creatorcontrib><description>Summary
Prior studies suggest an association between stressful life events and fractures that may be mediated by BMD. In the current study, risk of accelerated hip BMD loss was higher in older men with any type of stressful life event and increased with the number of types of stressful life events.
Introduction
Prior studies suggest that stressful life events may increase adverse health outcomes, including falls and possibly fractures. The current study builds on these findings and examines whether stressful life events are associated with increased bone loss.
Methods
Four thousand three hundred eighty-eight men aged ≥65 years in the Osteoporotic Fractures in Men study completed total hip bone mineral density (BMD) measures at baseline and visit 2, approximately 4.6 years later, and self-reported stressful life events data mid-way between baseline and visit 2, and at visit 2. We used linear regression to model the association of stressful life events with concurrent annualized total hip BMD loss, and log binomial regression or Poisson regression to model risk of concurrent accelerated BMD loss (>1 SD more than mean annualized change).
Results
Men (75.3 %) reported ≥1 type of stressful life event, including 43.3 % with ≥2 types of stressful life events. Mean annualized BMD loss was −0.36 % (SD 0.88), and 13.9 % of men were categorized with accelerated BMD loss (about 5.7 % or more total loss). Rate of annualized BMD loss increased with the number of types of stressful life events after adjustment for age (
p
< 0.001), but not after multivariable adjustment (
p
= 0.07). Multivariable-adjusted risk of accelerated BMD loss increased with the number of types of stressful life events (RR, 1.10 [95 % confidence interval (CI), 1.04–1.16]) per increase of one type of stressful life event). Fracture risk was not significantly different between stressful life event-accelerated bone loss subgroups (
p
= 0.08).
Conclusions
In these older men, stressful life events were associated with a small, dose-related increase in risk of concurrent accelerated hip bone loss. Low frequency of fractures limited assessment of whether rapid bone loss mediates any association of stressful life events with incident fractures. Future studies are needed to confirm these findings and to investigate the mechanism that may underlie this association.</description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-014-2853-8</identifier><identifier>PMID: 25169421</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Absorptiometry, Photon - methods ; Aged ; Aging ; Bone density ; Bone Density - physiology ; Disease Progression ; Endocrinology ; Hip Joint - physiopathology ; Humans ; Life Change Events ; Male ; Medicine ; Medicine & Public Health ; Men ; Older people ; Orthopedics ; Osteoporosis ; Osteoporosis - epidemiology ; Osteoporosis - etiology ; Osteoporosis - physiopathology ; Osteoporotic Fractures - epidemiology ; Osteoporotic Fractures - etiology ; Osteoporotic Fractures - physiopathology ; Rheumatology ; Risk Factors ; Short Communication ; Stress, Psychological - complications ; Stress, Psychological - epidemiology ; Stress, Psychological - physiopathology ; United States - epidemiology</subject><ispartof>Osteoporosis international, 2014-12, Vol.25 (12), p.2833-2839</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-6f77b34f757f7d3913da1d439cf412339d6afd766c321d96d045faafe49401403</citedby><cites>FETCH-LOGICAL-c540t-6f77b34f757f7d3913da1d439cf412339d6afd766c321d96d045faafe49401403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00198-014-2853-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00198-014-2853-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25169421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fink, H. A.</creatorcontrib><creatorcontrib>Kuskowski, M. A.</creatorcontrib><creatorcontrib>Cauley, J. A.</creatorcontrib><creatorcontrib>Taylor, B. C.</creatorcontrib><creatorcontrib>Schousboe, J. T.</creatorcontrib><creatorcontrib>Cawthon, P. M.</creatorcontrib><creatorcontrib>Ensrud, K. E.</creatorcontrib><creatorcontrib>Osteoporotic Fractures in Men (MrOS) Study Group</creatorcontrib><creatorcontrib>For the Osteoporotic Fractures in Men (MrOS) Study Group</creatorcontrib><title>Association of stressful life events with accelerated bone loss in older men: the osteoporotic fractures in men (MrOS) study</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><addtitle>Osteoporos Int</addtitle><description>Summary
Prior studies suggest an association between stressful life events and fractures that may be mediated by BMD. In the current study, risk of accelerated hip BMD loss was higher in older men with any type of stressful life event and increased with the number of types of stressful life events.
Introduction
Prior studies suggest that stressful life events may increase adverse health outcomes, including falls and possibly fractures. The current study builds on these findings and examines whether stressful life events are associated with increased bone loss.
Methods
Four thousand three hundred eighty-eight men aged ≥65 years in the Osteoporotic Fractures in Men study completed total hip bone mineral density (BMD) measures at baseline and visit 2, approximately 4.6 years later, and self-reported stressful life events data mid-way between baseline and visit 2, and at visit 2. We used linear regression to model the association of stressful life events with concurrent annualized total hip BMD loss, and log binomial regression or Poisson regression to model risk of concurrent accelerated BMD loss (>1 SD more than mean annualized change).
Results
Men (75.3 %) reported ≥1 type of stressful life event, including 43.3 % with ≥2 types of stressful life events. Mean annualized BMD loss was −0.36 % (SD 0.88), and 13.9 % of men were categorized with accelerated BMD loss (about 5.7 % or more total loss). Rate of annualized BMD loss increased with the number of types of stressful life events after adjustment for age (
p
< 0.001), but not after multivariable adjustment (
p
= 0.07). Multivariable-adjusted risk of accelerated BMD loss increased with the number of types of stressful life events (RR, 1.10 [95 % confidence interval (CI), 1.04–1.16]) per increase of one type of stressful life event). Fracture risk was not significantly different between stressful life event-accelerated bone loss subgroups (
p
= 0.08).
Conclusions
In these older men, stressful life events were associated with a small, dose-related increase in risk of concurrent accelerated hip bone loss. Low frequency of fractures limited assessment of whether rapid bone loss mediates any association of stressful life events with incident fractures. Future studies are needed to confirm these findings and to investigate the mechanism that may underlie this association.</description><subject>Absorptiometry, Photon - methods</subject><subject>Aged</subject><subject>Aging</subject><subject>Bone density</subject><subject>Bone Density - physiology</subject><subject>Disease Progression</subject><subject>Endocrinology</subject><subject>Hip Joint - physiopathology</subject><subject>Humans</subject><subject>Life Change Events</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Men</subject><subject>Older people</subject><subject>Orthopedics</subject><subject>Osteoporosis</subject><subject>Osteoporosis - epidemiology</subject><subject>Osteoporosis - etiology</subject><subject>Osteoporosis - physiopathology</subject><subject>Osteoporotic Fractures - epidemiology</subject><subject>Osteoporotic Fractures - etiology</subject><subject>Osteoporotic Fractures - physiopathology</subject><subject>Rheumatology</subject><subject>Risk Factors</subject><subject>Short Communication</subject><subject>Stress, Psychological - complications</subject><subject>Stress, Psychological - epidemiology</subject><subject>Stress, Psychological - physiopathology</subject><subject>United States - epidemiology</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kUFrFTEUhYMo9ln9AW4k4KYuRnMnmcnERaEUW4VKFyq4C3nJTV_KvMkzyVQK_ngzvFqq4CqL-51zc88h5CWwt8CYfJcZAzU0DETTDh1vhkdkBYLzplV995ismOKyUQK-H5BnOV-zqlFKPiUHbQe9Ei2syK-TnKMNpoQ40ehpLglz9vNIx-CR4g1OJdOfoWyosRZHTKago-s4IR1jzjRU2egw0S1O72nZII25YNzFFEuw1Cdjy1w9F7Ai9Ohzuvzypu6Z3e1z8sSbMeOLu_eQfDv78PX0Y3Nxef7p9OSisZ1gpem9lGsuvOykl44r4M6AE1xZL6DlXLneeCf73vIWnOodE503xqNQombD-CE53vvu5vUWna03JTPqXQpbk251NEH_PZnCRl_FG12zBBigGhzdGaT4Y8Zc9DbkmsZoJoxz1tC3LetByWXX63_Q6zinqZ63UKwexHlXKdhTNtUQE_r7zwDTS7d6362u_9dLt3qomlcPr7hX_CmzAu0eyHU0XWF6sPq_rr8BGIqwwA</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Fink, H. A.</creator><creator>Kuskowski, M. A.</creator><creator>Cauley, J. A.</creator><creator>Taylor, B. C.</creator><creator>Schousboe, J. T.</creator><creator>Cawthon, P. M.</creator><creator>Ensrud, K. E.</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20141201</creationdate><title>Association of stressful life events with accelerated bone loss in older men: the osteoporotic fractures in men (MrOS) study</title><author>Fink, H. A. ; Kuskowski, M. A. ; Cauley, J. A. ; Taylor, B. C. ; Schousboe, J. T. ; Cawthon, P. M. ; Ensrud, K. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-6f77b34f757f7d3913da1d439cf412339d6afd766c321d96d045faafe49401403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Absorptiometry, Photon - methods</topic><topic>Aged</topic><topic>Aging</topic><topic>Bone density</topic><topic>Bone Density - physiology</topic><topic>Disease Progression</topic><topic>Endocrinology</topic><topic>Hip Joint - physiopathology</topic><topic>Humans</topic><topic>Life Change Events</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Men</topic><topic>Older people</topic><topic>Orthopedics</topic><topic>Osteoporosis</topic><topic>Osteoporosis - epidemiology</topic><topic>Osteoporosis - etiology</topic><topic>Osteoporosis - physiopathology</topic><topic>Osteoporotic Fractures - epidemiology</topic><topic>Osteoporotic Fractures - etiology</topic><topic>Osteoporotic Fractures - physiopathology</topic><topic>Rheumatology</topic><topic>Risk Factors</topic><topic>Short Communication</topic><topic>Stress, Psychological - complications</topic><topic>Stress, Psychological - epidemiology</topic><topic>Stress, Psychological - physiopathology</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fink, H. A.</creatorcontrib><creatorcontrib>Kuskowski, M. A.</creatorcontrib><creatorcontrib>Cauley, J. A.</creatorcontrib><creatorcontrib>Taylor, B. C.</creatorcontrib><creatorcontrib>Schousboe, J. T.</creatorcontrib><creatorcontrib>Cawthon, P. M.</creatorcontrib><creatorcontrib>Ensrud, K. E.</creatorcontrib><creatorcontrib>Osteoporotic Fractures in Men (MrOS) Study Group</creatorcontrib><creatorcontrib>For the Osteoporotic Fractures in Men (MrOS) Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Osteoporosis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fink, H. A.</au><au>Kuskowski, M. A.</au><au>Cauley, J. A.</au><au>Taylor, B. C.</au><au>Schousboe, J. T.</au><au>Cawthon, P. M.</au><au>Ensrud, K. E.</au><aucorp>Osteoporotic Fractures in Men (MrOS) Study Group</aucorp><aucorp>For the Osteoporotic Fractures in Men (MrOS) Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of stressful life events with accelerated bone loss in older men: the osteoporotic fractures in men (MrOS) study</atitle><jtitle>Osteoporosis international</jtitle><stitle>Osteoporos Int</stitle><addtitle>Osteoporos Int</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>25</volume><issue>12</issue><spage>2833</spage><epage>2839</epage><pages>2833-2839</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>Summary
Prior studies suggest an association between stressful life events and fractures that may be mediated by BMD. In the current study, risk of accelerated hip BMD loss was higher in older men with any type of stressful life event and increased with the number of types of stressful life events.
Introduction
Prior studies suggest that stressful life events may increase adverse health outcomes, including falls and possibly fractures. The current study builds on these findings and examines whether stressful life events are associated with increased bone loss.
Methods
Four thousand three hundred eighty-eight men aged ≥65 years in the Osteoporotic Fractures in Men study completed total hip bone mineral density (BMD) measures at baseline and visit 2, approximately 4.6 years later, and self-reported stressful life events data mid-way between baseline and visit 2, and at visit 2. We used linear regression to model the association of stressful life events with concurrent annualized total hip BMD loss, and log binomial regression or Poisson regression to model risk of concurrent accelerated BMD loss (>1 SD more than mean annualized change).
Results
Men (75.3 %) reported ≥1 type of stressful life event, including 43.3 % with ≥2 types of stressful life events. Mean annualized BMD loss was −0.36 % (SD 0.88), and 13.9 % of men were categorized with accelerated BMD loss (about 5.7 % or more total loss). Rate of annualized BMD loss increased with the number of types of stressful life events after adjustment for age (
p
< 0.001), but not after multivariable adjustment (
p
= 0.07). Multivariable-adjusted risk of accelerated BMD loss increased with the number of types of stressful life events (RR, 1.10 [95 % confidence interval (CI), 1.04–1.16]) per increase of one type of stressful life event). Fracture risk was not significantly different between stressful life event-accelerated bone loss subgroups (
p
= 0.08).
Conclusions
In these older men, stressful life events were associated with a small, dose-related increase in risk of concurrent accelerated hip bone loss. Low frequency of fractures limited assessment of whether rapid bone loss mediates any association of stressful life events with incident fractures. Future studies are needed to confirm these findings and to investigate the mechanism that may underlie this association.</abstract><cop>London</cop><pub>Springer London</pub><pmid>25169421</pmid><doi>10.1007/s00198-014-2853-8</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0937-941X |
| ispartof | Osteoporosis international, 2014-12, Vol.25 (12), p.2833-2839 |
| issn | 0937-941X 1433-2965 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4331181 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Absorptiometry, Photon - methods Aged Aging Bone density Bone Density - physiology Disease Progression Endocrinology Hip Joint - physiopathology Humans Life Change Events Male Medicine Medicine & Public Health Men Older people Orthopedics Osteoporosis Osteoporosis - epidemiology Osteoporosis - etiology Osteoporosis - physiopathology Osteoporotic Fractures - epidemiology Osteoporotic Fractures - etiology Osteoporotic Fractures - physiopathology Rheumatology Risk Factors Short Communication Stress, Psychological - complications Stress, Psychological - epidemiology Stress, Psychological - physiopathology United States - epidemiology |
| title | Association of stressful life events with accelerated bone loss in older men: the osteoporotic fractures in men (MrOS) study |
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