Global Oct4 target gene analysis reveals novel downstream PTEN and TNC genes required for drug-resistance and metastasis in lung cancer

Overexpression of Oct4, a stemness gene encoding a transcription factor, has been reported in several cancers. However, the mechanism by which Oct4 directs transcriptional program that leads to somatic cancer progression remains unclear. In this study, we provide mechanistic insight into Oct4-driven...

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Veröffentlicht in:	Nucleic acids research 2015-02, Vol.43 (3), p.1593-1608
Hauptverfasser:	Tang, Yen-An, Chen, Chi-Hsin, Sun, H Sunny, Cheng, Chun-Pei, Tseng, Vincent S, Hsu, Han-Shui, Su, Wu-Chou, Lai, Wu-Wei, Wang, Yi-Ching
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Chromatin Immunoprecipitation Drug Resistance, Neoplasm - genetics Gene regulation, Chromatin and Epigenetics Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Neoplasm Metastasis - genetics Octamer Transcription Factor-3 - genetics Polymerase Chain Reaction Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - genetics Signal Transduction Tenascin - genetics Transcription, Genetic
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