FoxP3 interacts with linker histone H1.5 to modulate gene expression and program Treg cell activity

The forkhead box transcription factor FoxP3 controls the development and function of CD4+CD25+ regulatory T (Treg) cell. FoxP3 modulates gene expression in Treg cells by multiple epigenetic mechanisms that are not clearly defined. We identified FoxP3-interacting proteins in human T cells by co-immun...

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Veröffentlicht in:	Genes and immunity 2011-10, Vol.12 (7), p.559-567
Hauptverfasser:	Mackey-Cushman, S L, Gao, J, Holmes, D A, Nunoya, J-i, Wang, R, Unutmaz, D, Su, L
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/200 631/250/1619/554/1898/1271 Acetylation Amino Acid Sequence Antibodies Biomedical and Life Sciences Biomedicine Cancer Research CD25 antigen CD4 antigen Cells, Cultured CTLA-4 Antigen - genetics CTLA-4 Antigen - immunology CTLA-4 protein Cytokines DNA binding proteins DNA methylation Epigenetics Forkhead protein Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Foxp3 protein Gene Expression Gene Expression Regulation HEK293 Cells Histone H1 Histones Histones - metabolism Human Genetics Humans Immunology Immunoprecipitation Interleukin 2 Interleukin-2 - genetics Interleukin-2 - immunology Jurkat Cells Leucine zipper proteins Lymphocytes Lymphocytes T Mutation original-article Physiological aspects Promoter Regions, Genetic Protein Binding Proteins T cells T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Transcription factors
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