Gene expression signatures in motor neurone disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions

Aims Amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) are two syndromic variants within the motor neurone disease spectrum. As PLS and most ALS cases are sporadic (SALS), this limits the availability of cellular models for investigating pathogenic mechanisms and therapeutic ta...

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Veröffentlicht in:	Neuropathology and applied neurobiology 2015-02, Vol.41 (2), p.201-226
Hauptverfasser:	Raman, Rohini, Allen, Scott P, Goodall, Emily F, Kramer, Shelley, Ponger, Lize-Linde, Heath, Paul R., Milo, Marta, Hollinger, Hannah C., Walsh, Theresa, Highley, J Robin, Olpin, Simon, McDermott, Christopher J., Shaw, Pamela J., Kirby, Janine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Amyotrophic lateral sclerosis Cell Hypoxia - physiology cell models Cells, Cultured Female fibroblasts Fibroblasts - metabolism Fibroblasts - pathology Gene expression Gene Expression Profiling - methods Humans Hypoxia hypoxia response Immunoblotting Male Medical research microarray microRNA MicroRNAs - analysis Middle Aged Motor Neuron Disease - genetics Motor Neuron Disease - metabolism Motor Neuron Disease - pathology Oligonucleotide Array Sequence Analysis - methods Original primary lateral sclerosis Transcriptome
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