An investigation of drug-resistant Acinetobacter baumannii infections in a comprehensive hospital of East China
To investigate the drug resistant gene profiles and molecular typing of Acinetobacter baumannii isolates collected from clinical specimens in a comprehensive hospital, Jiangsu province. This study included 120 patients in a comprehensive hospital with drug-resistant A. baumannii infections on clinic...
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| Veröffentlicht in: | Annals of clinical microbiology and antimicrobials 2015-02, Vol.14 (1), p.7-7, Article 7 |
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| creator | Zhao, Su-ying Jiang, Dong-yang Xu, Peng-cheng Zhang, Yi-kai Shi, Heng-fang Cao, Hui-ling Wu, Qian |
| description | To investigate the drug resistant gene profiles and molecular typing of Acinetobacter baumannii isolates collected from clinical specimens in a comprehensive hospital, Jiangsu province.
This study included 120 patients in a comprehensive hospital with drug-resistant A. baumannii infections on clinical specimens from October 2011 to December 2013. Antibiotic susceptibility test was determined by Vitek 2 Compact system. OXA-51, OXA-23, OXA-24, OXA-58, VIM, IMP, SHV, GES, TEM, AmpC, qacEΔ1-sul1, intI l, CarO, aac(6')-Ib, and aac(6')-II were analyzed by PCR. The analysis of molecular typing for 50 multidrug resistant A. baumannii isolates was performed by PFGE.
A total of 64(53%) isolates were multidrug-resistant A.baumannii. The antibiotic susceptibility tests showed that the resistant rates to common antibiotics of mutidrug-resistant A. baumannii were extremely high, most of which over 60%. One hundred and ten isolates harbored OXA-51 (91.7%), 100 for OXA-23(83.3%), 103 for VIM-1(85.8%), 90 for AmpC(75.00%), 50 for aac(6')-Ib(41.7%), 77 for the loss of CarO (64.2%), 85 for intl1(70.8%), and 64 for qacEΔ1-sul1(53.33%), while OXA-24 was undetected. Fifty multidrug-resistant A. baumannii isolates belong to 14 clones according to the PFGE DNA patterns. Main clone A includes 24 isolates, while clone B and clone C includes 6 and 9 isolates, respectively and others with no common source identified.
There is high morbidity of A. baumannii infections in the hospital, especially in ICU and sputum is the most common sample type.The mainly drug-resistant genes of A. baumannii are OXA-51, OXA-23, and VIM-1 in the hospital. Clonal dissemination provides evidence for the prevalence of multidrug-resistant A. baumannii among clinical isolates. It is suggested that there is an urgent need for effective control and prevention measures. |
| doi_str_mv | 10.1186/s12941-015-0066-4 |
| format | Article |
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This study included 120 patients in a comprehensive hospital with drug-resistant A. baumannii infections on clinical specimens from October 2011 to December 2013. Antibiotic susceptibility test was determined by Vitek 2 Compact system. OXA-51, OXA-23, OXA-24, OXA-58, VIM, IMP, SHV, GES, TEM, AmpC, qacEΔ1-sul1, intI l, CarO, aac(6')-Ib, and aac(6')-II were analyzed by PCR. The analysis of molecular typing for 50 multidrug resistant A. baumannii isolates was performed by PFGE.
A total of 64(53%) isolates were multidrug-resistant A.baumannii. The antibiotic susceptibility tests showed that the resistant rates to common antibiotics of mutidrug-resistant A. baumannii were extremely high, most of which over 60%. One hundred and ten isolates harbored OXA-51 (91.7%), 100 for OXA-23(83.3%), 103 for VIM-1(85.8%), 90 for AmpC(75.00%), 50 for aac(6')-Ib(41.7%), 77 for the loss of CarO (64.2%), 85 for intl1(70.8%), and 64 for qacEΔ1-sul1(53.33%), while OXA-24 was undetected. Fifty multidrug-resistant A. baumannii isolates belong to 14 clones according to the PFGE DNA patterns. Main clone A includes 24 isolates, while clone B and clone C includes 6 and 9 isolates, respectively and others with no common source identified.
There is high morbidity of A. baumannii infections in the hospital, especially in ICU and sputum is the most common sample type.The mainly drug-resistant genes of A. baumannii are OXA-51, OXA-23, and VIM-1 in the hospital. Clonal dissemination provides evidence for the prevalence of multidrug-resistant A. baumannii among clinical isolates. It is suggested that there is an urgent need for effective control and prevention measures.</description><identifier>ISSN: 1476-0711</identifier><identifier>EISSN: 1476-0711</identifier><identifier>DOI: 10.1186/s12941-015-0066-4</identifier><identifier>PMID: 25643932</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Acinetobacter baumannii - classification ; Acinetobacter baumannii - drug effects ; Acinetobacter baumannii - genetics ; Acinetobacter baumannii - isolation & purification ; Acinetobacter Infections - epidemiology ; Acinetobacter Infections - microbiology ; Adult ; Aged ; Aged, 80 and over ; Analysis ; Anti-Bacterial Agents - pharmacology ; Antibiotics ; Bacterial infections ; Bacterial Proteins - genetics ; China - epidemiology ; Cross Infection - epidemiology ; Cross Infection - microbiology ; Drug resistance ; Drug resistance in microorganisms ; Drug Resistance, Multiple, Bacterial ; Female ; Genetic aspects ; Health aspects ; Hospitals - statistics & numerical data ; Humans ; Infection ; Male ; Medical research ; Medicine, Experimental ; Methods ; Microbial Sensitivity Tests ; Microbiology ; Middle Aged ; Physiological aspects ; Young Adult</subject><ispartof>Annals of clinical microbiology and antimicrobials, 2015-02, Vol.14 (1), p.7-7, Article 7</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2015</rights><rights>Zhao et al.; licensee BioMed Central. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b555t-57c4e8306aa3486c10db11695a00a778a1563b0b4d2033287a3b926a04c2b6c63</citedby><cites>FETCH-LOGICAL-b555t-57c4e8306aa3486c10db11695a00a778a1563b0b4d2033287a3b926a04c2b6c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328433/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328433/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25643932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Su-ying</creatorcontrib><creatorcontrib>Jiang, Dong-yang</creatorcontrib><creatorcontrib>Xu, Peng-cheng</creatorcontrib><creatorcontrib>Zhang, Yi-kai</creatorcontrib><creatorcontrib>Shi, Heng-fang</creatorcontrib><creatorcontrib>Cao, Hui-ling</creatorcontrib><creatorcontrib>Wu, Qian</creatorcontrib><title>An investigation of drug-resistant Acinetobacter baumannii infections in a comprehensive hospital of East China</title><title>Annals of clinical microbiology and antimicrobials</title><addtitle>Ann Clin Microbiol Antimicrob</addtitle><description>To investigate the drug resistant gene profiles and molecular typing of Acinetobacter baumannii isolates collected from clinical specimens in a comprehensive hospital, Jiangsu province.
This study included 120 patients in a comprehensive hospital with drug-resistant A. baumannii infections on clinical specimens from October 2011 to December 2013. Antibiotic susceptibility test was determined by Vitek 2 Compact system. OXA-51, OXA-23, OXA-24, OXA-58, VIM, IMP, SHV, GES, TEM, AmpC, qacEΔ1-sul1, intI l, CarO, aac(6')-Ib, and aac(6')-II were analyzed by PCR. The analysis of molecular typing for 50 multidrug resistant A. baumannii isolates was performed by PFGE.
A total of 64(53%) isolates were multidrug-resistant A.baumannii. The antibiotic susceptibility tests showed that the resistant rates to common antibiotics of mutidrug-resistant A. baumannii were extremely high, most of which over 60%. One hundred and ten isolates harbored OXA-51 (91.7%), 100 for OXA-23(83.3%), 103 for VIM-1(85.8%), 90 for AmpC(75.00%), 50 for aac(6')-Ib(41.7%), 77 for the loss of CarO (64.2%), 85 for intl1(70.8%), and 64 for qacEΔ1-sul1(53.33%), while OXA-24 was undetected. Fifty multidrug-resistant A. baumannii isolates belong to 14 clones according to the PFGE DNA patterns. Main clone A includes 24 isolates, while clone B and clone C includes 6 and 9 isolates, respectively and others with no common source identified.
There is high morbidity of A. baumannii infections in the hospital, especially in ICU and sputum is the most common sample type.The mainly drug-resistant genes of A. baumannii are OXA-51, OXA-23, and VIM-1 in the hospital. Clonal dissemination provides evidence for the prevalence of multidrug-resistant A. baumannii among clinical isolates. It is suggested that there is an urgent need for effective control and prevention measures.</description><subject>Acinetobacter baumannii - classification</subject><subject>Acinetobacter baumannii - drug effects</subject><subject>Acinetobacter baumannii - genetics</subject><subject>Acinetobacter baumannii - isolation & purification</subject><subject>Acinetobacter Infections - epidemiology</subject><subject>Acinetobacter Infections - microbiology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics</subject><subject>Bacterial infections</subject><subject>Bacterial Proteins - genetics</subject><subject>China - epidemiology</subject><subject>Cross Infection - epidemiology</subject><subject>Cross Infection - microbiology</subject><subject>Drug resistance</subject><subject>Drug resistance in microorganisms</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Hospitals - statistics & numerical data</subject><subject>Humans</subject><subject>Infection</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Methods</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Physiological aspects</subject><subject>Young Adult</subject><issn>1476-0711</issn><issn>1476-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1Uk2LFDEQDaK46-gP8CINXrz0mu_0XIRhXD9gwYueQyWdnsnSnYxJesB_b5pZ1x1ZySFF6r2XqnqF0GuCrwjp5PtM6JqTFhPRYixly5-gS8KVbLEi5OmD-AK9yPkWY1ph6jm6oEJytmb0EsVNaHw4ulz8DoqPoYlD06d51yaXfS4QSrOxPrgSDdjiUmNgniAE7ytvcHbh5Bo20Ng4HZLbu5D90TX7mA--wLgIXkMuzXbvA7xEzwYYs3t1d6_Qj0_X37df2ptvn79uNzetEUKUVijLXcewBGC8k5bg3hAi1wIwBqU6IEIygw3vKWaMdgqYWVMJmFtqpJVshT6cdA-zmVxvXSgJRn1IfoL0S0fw-jwT_F7v4lHzqsYZqwIfTwLGx_8InGdq9_pkiK6G6MWQKrZC7-7qSPHnXMesJ5-tG0cILs5ZE6m47KQQuELf_gO9jXMKdUqaqA4LJajif1E7GJ2uFsT6u11E9UZwwrtOqaX6q0dQ9fRu8jYGN_j6fkYgJ4JNMefkhvtOCdbLsj3a25uHM75n_Nku9huU7s-t</recordid><startdate>20150203</startdate><enddate>20150203</enddate><creator>Zhao, Su-ying</creator><creator>Jiang, Dong-yang</creator><creator>Xu, Peng-cheng</creator><creator>Zhang, Yi-kai</creator><creator>Shi, Heng-fang</creator><creator>Cao, Hui-ling</creator><creator>Wu, Qian</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150203</creationdate><title>An investigation of drug-resistant Acinetobacter baumannii infections in a comprehensive hospital of East China</title><author>Zhao, Su-ying ; Jiang, Dong-yang ; Xu, Peng-cheng ; Zhang, Yi-kai ; Shi, Heng-fang ; Cao, Hui-ling ; Wu, Qian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b555t-57c4e8306aa3486c10db11695a00a778a1563b0b4d2033287a3b926a04c2b6c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acinetobacter baumannii - classification</topic><topic>Acinetobacter baumannii - drug effects</topic><topic>Acinetobacter baumannii - genetics</topic><topic>Acinetobacter baumannii - isolation & purification</topic><topic>Acinetobacter Infections - epidemiology</topic><topic>Acinetobacter Infections - microbiology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics</topic><topic>Bacterial infections</topic><topic>Bacterial Proteins - genetics</topic><topic>China - epidemiology</topic><topic>Cross Infection - epidemiology</topic><topic>Cross Infection - microbiology</topic><topic>Drug resistance</topic><topic>Drug resistance in microorganisms</topic><topic>Drug Resistance, Multiple, Bacterial</topic><topic>Female</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Hospitals - statistics & numerical data</topic><topic>Humans</topic><topic>Infection</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Methods</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Physiological aspects</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Su-ying</creatorcontrib><creatorcontrib>Jiang, Dong-yang</creatorcontrib><creatorcontrib>Xu, Peng-cheng</creatorcontrib><creatorcontrib>Zhang, Yi-kai</creatorcontrib><creatorcontrib>Shi, Heng-fang</creatorcontrib><creatorcontrib>Cao, Hui-ling</creatorcontrib><creatorcontrib>Wu, Qian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of clinical microbiology and antimicrobials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Su-ying</au><au>Jiang, Dong-yang</au><au>Xu, Peng-cheng</au><au>Zhang, Yi-kai</au><au>Shi, Heng-fang</au><au>Cao, Hui-ling</au><au>Wu, Qian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An investigation of drug-resistant Acinetobacter baumannii infections in a comprehensive hospital of East China</atitle><jtitle>Annals of clinical microbiology and antimicrobials</jtitle><addtitle>Ann Clin Microbiol Antimicrob</addtitle><date>2015-02-03</date><risdate>2015</risdate><volume>14</volume><issue>1</issue><spage>7</spage><epage>7</epage><pages>7-7</pages><artnum>7</artnum><issn>1476-0711</issn><eissn>1476-0711</eissn><abstract>To investigate the drug resistant gene profiles and molecular typing of Acinetobacter baumannii isolates collected from clinical specimens in a comprehensive hospital, Jiangsu province.
This study included 120 patients in a comprehensive hospital with drug-resistant A. baumannii infections on clinical specimens from October 2011 to December 2013. Antibiotic susceptibility test was determined by Vitek 2 Compact system. OXA-51, OXA-23, OXA-24, OXA-58, VIM, IMP, SHV, GES, TEM, AmpC, qacEΔ1-sul1, intI l, CarO, aac(6')-Ib, and aac(6')-II were analyzed by PCR. The analysis of molecular typing for 50 multidrug resistant A. baumannii isolates was performed by PFGE.
A total of 64(53%) isolates were multidrug-resistant A.baumannii. The antibiotic susceptibility tests showed that the resistant rates to common antibiotics of mutidrug-resistant A. baumannii were extremely high, most of which over 60%. One hundred and ten isolates harbored OXA-51 (91.7%), 100 for OXA-23(83.3%), 103 for VIM-1(85.8%), 90 for AmpC(75.00%), 50 for aac(6')-Ib(41.7%), 77 for the loss of CarO (64.2%), 85 for intl1(70.8%), and 64 for qacEΔ1-sul1(53.33%), while OXA-24 was undetected. Fifty multidrug-resistant A. baumannii isolates belong to 14 clones according to the PFGE DNA patterns. Main clone A includes 24 isolates, while clone B and clone C includes 6 and 9 isolates, respectively and others with no common source identified.
There is high morbidity of A. baumannii infections in the hospital, especially in ICU and sputum is the most common sample type.The mainly drug-resistant genes of A. baumannii are OXA-51, OXA-23, and VIM-1 in the hospital. Clonal dissemination provides evidence for the prevalence of multidrug-resistant A. baumannii among clinical isolates. It is suggested that there is an urgent need for effective control and prevention measures.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>25643932</pmid><doi>10.1186/s12941-015-0066-4</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; SpringerLink Journals - AutoHoldings; PubMed Central Open Access; Springer Nature OA Free Journals |
| subjects | Acinetobacter baumannii - classification Acinetobacter baumannii - drug effects Acinetobacter baumannii - genetics Acinetobacter baumannii - isolation & purification Acinetobacter Infections - epidemiology Acinetobacter Infections - microbiology Adult Aged Aged, 80 and over Analysis Anti-Bacterial Agents - pharmacology Antibiotics Bacterial infections Bacterial Proteins - genetics China - epidemiology Cross Infection - epidemiology Cross Infection - microbiology Drug resistance Drug resistance in microorganisms Drug Resistance, Multiple, Bacterial Female Genetic aspects Health aspects Hospitals - statistics & numerical data Humans Infection Male Medical research Medicine, Experimental Methods Microbial Sensitivity Tests Microbiology Middle Aged Physiological aspects Young Adult |
| title | An investigation of drug-resistant Acinetobacter baumannii infections in a comprehensive hospital of East China |
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