Granzyme B mediates both direct and indirect cleavage of extracellular matrix in skin after chronic low‐dose ultraviolet light irradiation

Summary Extracellular matrix (ECM) degradation is a hallmark of many chronic inflammatory diseases that can lead to a loss of function, aging, and disease progression. Ultraviolet light (UV) irradiation from the sun is widely considered as the major cause of visible human skin aging, causing increas...

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Veröffentlicht in:	Aging cell 2015-02, Vol.14 (1), p.67-77
Hauptverfasser:	Parkinson, Leigh G., Toro, Ana, Zhao, Hongyan, Brown, Keddie, Tebbutt, Scott J., Granville, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Animals B cells Care and treatment Cell Count Collagen Collagen - metabolism Decorin - metabolism Dermis - pathology Dermis - radiation effects Dose-Response Relationship, Radiation extracellular matrix Extracellular Matrix - metabolism Female Fibroblasts - enzymology Fibroblasts - radiation effects fibronectin Fibronectins Fibronectins - metabolism granzyme B Granzymes - deficiency Granzymes - metabolism Mast Cells - enzymology Mast Cells - radiation effects matrix metalloproteinase Matrix Metalloproteinase 1 - metabolism Mice, Inbred C57BL Mice, Knockout Models, Biological Original photoaging Proteases Protein Transport - radiation effects Proteolysis - radiation effects Skin Skin - metabolism Skin - radiation effects Skin Aging - radiation effects ultraviolet light Ultraviolet radiation Ultraviolet Rays
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