miR-122 Stimulates Hepatitis C Virus RNA Synthesis by Altering the Balance of Viral RNAs Engaged in Replication versus Translation

The liver-specific microRNA, miR-122, stabilizes hepatitis C virus (HCV) RNA genomes by recruiting host argonaute 2 (AGO2) to the 5′ end and preventing decay mediated by exonuclease Xrn1. However, HCV replication requires miR-122 in Xrn1-depleted cells, indicating additional functions. We show that...

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Veröffentlicht in:	Cell host & microbe 2015-02, Vol.17 (2), p.217-228
Hauptverfasser:	Masaki, Takahiro, Arend, Kyle C., Li, You, Yamane, Daisuke, McGivern, David R., Kato, Takanobu, Wakita, Takaji, Moorman, Nathaniel J., Lemon, Stanley M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Gene Expression Regulation, Viral Hepacivirus - physiology Host-Pathogen Interactions Humans MicroRNAs - metabolism Protein Biosynthesis RNA, Viral - metabolism RNA-Binding Proteins - antagonists & inhibitors Transcription, Genetic Virus Replication
Online-Zugang:	Volltext
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