Asef controls vascular endothelial permeability and barrier recovery in the lung

Increased levels of hepatocyte growth factor (HGF) in injured lungs may reflect a compensatory response to diminish acute lung injury (ALI). HGF-induced activation of Rac1 GTPase stimulates endothelial barrier protective mechanisms. This study tested the involvement of Rac-specific guanine nucleotid...

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Veröffentlicht in:	Molecular biology of the cell 2015-02, Vol.26 (4), p.636-650
Hauptverfasser:	Tian, Xinyong, Tian, Yufeng, Gawlak, Grzegorz, Meng, Fanyong, Kawasaki, Yoshihiro, Akiyama, Tetsu, Birukova, Anna A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Membrane Permeability Gene Knockdown Techniques Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - metabolism Guanine Nucleotide Exchange Factors - physiology Hepatocyte Growth Factor - pharmacology Lung - metabolism Mice rac1 GTP-Binding Protein - metabolism RNA Interference Signal Transduction
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