Lymph node but not intradermal injection site macrophages are critical for germinal center formation and antibody responses to rabies vaccination

Replication-deficient rabies virus (RABV)-based vaccines induce rapid and potent antibody responses via T cell-independent and T cell-dependent mechanisms. To further investigate early events in vaccine-induced antibody responses against RABV infections, we studied the role of macrophages as mediato...

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Veröffentlicht in:	Journal of virology 2015-03, Vol.89 (5), p.2842-2848
Hauptverfasser:	Lytle, Andrew G, Shen, Shixue, McGettigan, James P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - blood Antibody Formation B-Lymphocytes - immunology Female Germinal Center - immunology Injections, Intradermal Lymph Nodes - immunology Macrophages - immunology Mice, Inbred C57BL Rabies Vaccines - administration & dosage Rabies Vaccines - immunology Rabies virus T-Lymphocytes, Helper-Inducer - immunology Vaccines and Antiviral Agents
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