Neurocognitive functioning in a Romanian cohort of young adults with parenterally-acquired HIV-infection during childhood
The Romanian cohort can provide valuable information about the effect of chronic HIV-infection and exposure to combined antiretroviral therapy (cART) on the developing brain, based on its unique characteristics: young adults infected parenterally with HIV clade F in the late 1980s and exposed to cAR...
Gespeichert in:
| Veröffentlicht in: | Journal of neurovirology 2014-10, Vol.20 (5), p.496-504 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 504 |
|---|---|
| container_issue | 5 |
| container_start_page | 496 |
| container_title | Journal of neurovirology |
| container_volume | 20 |
| creator | Ene, Luminita Franklin, Donald R. Burlacu, Ruxandra Luca, Anca E. Blaglosov, Andreea G. Ellis, Ronald J. Alexander, Terry J. Umlauf, Anya Grant, Igor Duiculescu, Dan C. Achim, Cristian L. Marcotte, Thomas D. |
| description | The Romanian cohort can provide valuable information about the effect of chronic HIV-infection and exposure to combined antiretroviral therapy (cART) on the developing brain, based on its unique characteristics: young adults infected parenterally with HIV clade F in the late 1980s and exposed to cART for a decade. We conducted a prospective study using a neuropsychological test battery validated in other international HIV cohorts, in order to evaluate the rate and severity of neurocognitive impairment in a group of young Romanian adults. The 49 HIV-infected (HIV+) participants and the 20 HIV negative (HIV−) controls were similar for age and gender, although the HIV− group tended to be more educated. We found higher cognitive impairment prevalence in the HIV+ group (59.1 %) versus the HIV− group (10 %), and the impairment rate remained significantly higher even when the groups were matched based on the educational level (38.7 % for the HIV+ group vs. 10.0 % for the HIV− controls;
p
= 0.025). The nadir CD4 count was |
| doi_str_mv | 10.1007/s13365-014-0275-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4324616</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1615258060</sourcerecordid><originalsourceid>FETCH-LOGICAL-c545t-f64b103e2a8db651ad35c8ac684bac1a779ec6694684687a21e3c8b909d788803</originalsourceid><addsrcrecordid>eNqNkU1rFTEYhYNYbK3-ADeSpZtoviezEaRUWygWSnUbMknmTsrc5DaZVO6_N-OtRTfiKiHnvA8n7wHgDcHvCcbdh0IYkwJhwhGmnUDkGTghgilEOWfP252JplLFj8HLUu4wJkxS9QIcU0GUUFKdgP1XX3OyaRPDEh48HGu0S0gxxA0MERp4k7YmBhOhTVPKC0wj3KfaVOPqvBT4IywT3Jns4-Kzmec9Mva-huwdvLj8jkIc_S8gdDWvUDuF2U0puVfgaDRz8a8fz1Pw7fP57dkFurr-cnn26QpZwcWCRskHgpmnRrlBCmIcE1YZKxUfjCWm63pvpex5e5CqM5R4ZtXQ4951SinMTsHHA3dXh613tgVtOfUuh63Je51M0H8rMUx6kx40Z5RLIhvg3SMgp_vqy6K3oVg_zyb6VItuFoFpz3r2H1YiqFBYrrHIwWpzKiX78SkRwXptVx_a1a1dvbarSZt5--dXniZ-19kM9GAou3XZPuu7VHNs6_0H9ScoorK8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1615258060</pqid></control><display><type>article</type><title>Neurocognitive functioning in a Romanian cohort of young adults with parenterally-acquired HIV-infection during childhood</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Ene, Luminita ; Franklin, Donald R. ; Burlacu, Ruxandra ; Luca, Anca E. ; Blaglosov, Andreea G. ; Ellis, Ronald J. ; Alexander, Terry J. ; Umlauf, Anya ; Grant, Igor ; Duiculescu, Dan C. ; Achim, Cristian L. ; Marcotte, Thomas D.</creator><creatorcontrib>Ene, Luminita ; Franklin, Donald R. ; Burlacu, Ruxandra ; Luca, Anca E. ; Blaglosov, Andreea G. ; Ellis, Ronald J. ; Alexander, Terry J. ; Umlauf, Anya ; Grant, Igor ; Duiculescu, Dan C. ; Achim, Cristian L. ; Marcotte, Thomas D.</creatorcontrib><description>The Romanian cohort can provide valuable information about the effect of chronic HIV-infection and exposure to combined antiretroviral therapy (cART) on the developing brain, based on its unique characteristics: young adults infected parenterally with HIV clade F in the late 1980s and exposed to cART for a decade. We conducted a prospective study using a neuropsychological test battery validated in other international HIV cohorts, in order to evaluate the rate and severity of neurocognitive impairment in a group of young Romanian adults. The 49 HIV-infected (HIV+) participants and the 20 HIV negative (HIV−) controls were similar for age and gender, although the HIV− group tended to be more educated. We found higher cognitive impairment prevalence in the HIV+ group (59.1 %) versus the HIV− group (10 %), and the impairment rate remained significantly higher even when the groups were matched based on the educational level (38.7 % for the HIV+ group vs. 10.0 % for the HIV− controls;
p
= 0.025). The nadir CD4 count was <200 in 71.4 % of patients, but at the time of neurocognitive assessment, 89.5 % of patients had normal immunological status and 81.8 % undetectable HIV load. Among the HIV-impaired group, 26 % of the participants had syndromic impairment while the other 74 % had asymptomatic neurocognitive impairment. We found a high prevalence of neurocognitive dysfunction in the Romanian young adults growing-up with HIV. The greatest HIV-related cognitive deficits were in the domains of executive and motor functioning, consistent with a frontosubcortical pattern.</description><identifier>ISSN: 1355-0284</identifier><identifier>EISSN: 1538-2443</identifier><identifier>DOI: 10.1007/s13365-014-0275-1</identifier><identifier>PMID: 25185868</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adolescent ; Biomedical and Life Sciences ; Biomedicine ; Cognition Disorders - epidemiology ; Cognition Disorders - virology ; Cohort Studies ; Female ; HIV Infections - complications ; Human immunodeficiency virus ; Humans ; Immunology ; Infectious Diseases ; Male ; Neurology ; Neuropsychological Tests ; Neurosciences ; Prevalence ; Romania - epidemiology ; Virology ; Young Adult</subject><ispartof>Journal of neurovirology, 2014-10, Vol.20 (5), p.496-504</ispartof><rights>Journal of NeuroVirology, Inc. 2014</rights><rights>Journal of NeuroVirology, Inc. 2014 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c545t-f64b103e2a8db651ad35c8ac684bac1a779ec6694684687a21e3c8b909d788803</citedby><cites>FETCH-LOGICAL-c545t-f64b103e2a8db651ad35c8ac684bac1a779ec6694684687a21e3c8b909d788803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13365-014-0275-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13365-014-0275-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25185868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ene, Luminita</creatorcontrib><creatorcontrib>Franklin, Donald R.</creatorcontrib><creatorcontrib>Burlacu, Ruxandra</creatorcontrib><creatorcontrib>Luca, Anca E.</creatorcontrib><creatorcontrib>Blaglosov, Andreea G.</creatorcontrib><creatorcontrib>Ellis, Ronald J.</creatorcontrib><creatorcontrib>Alexander, Terry J.</creatorcontrib><creatorcontrib>Umlauf, Anya</creatorcontrib><creatorcontrib>Grant, Igor</creatorcontrib><creatorcontrib>Duiculescu, Dan C.</creatorcontrib><creatorcontrib>Achim, Cristian L.</creatorcontrib><creatorcontrib>Marcotte, Thomas D.</creatorcontrib><title>Neurocognitive functioning in a Romanian cohort of young adults with parenterally-acquired HIV-infection during childhood</title><title>Journal of neurovirology</title><addtitle>J. Neurovirol</addtitle><addtitle>J Neurovirol</addtitle><description>The Romanian cohort can provide valuable information about the effect of chronic HIV-infection and exposure to combined antiretroviral therapy (cART) on the developing brain, based on its unique characteristics: young adults infected parenterally with HIV clade F in the late 1980s and exposed to cART for a decade. We conducted a prospective study using a neuropsychological test battery validated in other international HIV cohorts, in order to evaluate the rate and severity of neurocognitive impairment in a group of young Romanian adults. The 49 HIV-infected (HIV+) participants and the 20 HIV negative (HIV−) controls were similar for age and gender, although the HIV− group tended to be more educated. We found higher cognitive impairment prevalence in the HIV+ group (59.1 %) versus the HIV− group (10 %), and the impairment rate remained significantly higher even when the groups were matched based on the educational level (38.7 % for the HIV+ group vs. 10.0 % for the HIV− controls;
p
= 0.025). The nadir CD4 count was <200 in 71.4 % of patients, but at the time of neurocognitive assessment, 89.5 % of patients had normal immunological status and 81.8 % undetectable HIV load. Among the HIV-impaired group, 26 % of the participants had syndromic impairment while the other 74 % had asymptomatic neurocognitive impairment. We found a high prevalence of neurocognitive dysfunction in the Romanian young adults growing-up with HIV. The greatest HIV-related cognitive deficits were in the domains of executive and motor functioning, consistent with a frontosubcortical pattern.</description><subject>Adolescent</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cognition Disorders - epidemiology</subject><subject>Cognition Disorders - virology</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>HIV Infections - complications</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunology</subject><subject>Infectious Diseases</subject><subject>Male</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Neurosciences</subject><subject>Prevalence</subject><subject>Romania - epidemiology</subject><subject>Virology</subject><subject>Young Adult</subject><issn>1355-0284</issn><issn>1538-2443</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1rFTEYhYNYbK3-ADeSpZtoviezEaRUWygWSnUbMknmTsrc5DaZVO6_N-OtRTfiKiHnvA8n7wHgDcHvCcbdh0IYkwJhwhGmnUDkGTghgilEOWfP252JplLFj8HLUu4wJkxS9QIcU0GUUFKdgP1XX3OyaRPDEh48HGu0S0gxxA0MERp4k7YmBhOhTVPKC0wj3KfaVOPqvBT4IywT3Jns4-Kzmec9Mva-huwdvLj8jkIc_S8gdDWvUDuF2U0puVfgaDRz8a8fz1Pw7fP57dkFurr-cnn26QpZwcWCRskHgpmnRrlBCmIcE1YZKxUfjCWm63pvpex5e5CqM5R4ZtXQ4951SinMTsHHA3dXh613tgVtOfUuh63Je51M0H8rMUx6kx40Z5RLIhvg3SMgp_vqy6K3oVg_zyb6VItuFoFpz3r2H1YiqFBYrrHIwWpzKiX78SkRwXptVx_a1a1dvbarSZt5--dXniZ-19kM9GAou3XZPuu7VHNs6_0H9ScoorK8</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Ene, Luminita</creator><creator>Franklin, Donald R.</creator><creator>Burlacu, Ruxandra</creator><creator>Luca, Anca E.</creator><creator>Blaglosov, Andreea G.</creator><creator>Ellis, Ronald J.</creator><creator>Alexander, Terry J.</creator><creator>Umlauf, Anya</creator><creator>Grant, Igor</creator><creator>Duiculescu, Dan C.</creator><creator>Achim, Cristian L.</creator><creator>Marcotte, Thomas D.</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20141001</creationdate><title>Neurocognitive functioning in a Romanian cohort of young adults with parenterally-acquired HIV-infection during childhood</title><author>Ene, Luminita ; Franklin, Donald R. ; Burlacu, Ruxandra ; Luca, Anca E. ; Blaglosov, Andreea G. ; Ellis, Ronald J. ; Alexander, Terry J. ; Umlauf, Anya ; Grant, Igor ; Duiculescu, Dan C. ; Achim, Cristian L. ; Marcotte, Thomas D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c545t-f64b103e2a8db651ad35c8ac684bac1a779ec6694684687a21e3c8b909d788803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cognition Disorders - epidemiology</topic><topic>Cognition Disorders - virology</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>HIV Infections - complications</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immunology</topic><topic>Infectious Diseases</topic><topic>Male</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Neurosciences</topic><topic>Prevalence</topic><topic>Romania - epidemiology</topic><topic>Virology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ene, Luminita</creatorcontrib><creatorcontrib>Franklin, Donald R.</creatorcontrib><creatorcontrib>Burlacu, Ruxandra</creatorcontrib><creatorcontrib>Luca, Anca E.</creatorcontrib><creatorcontrib>Blaglosov, Andreea G.</creatorcontrib><creatorcontrib>Ellis, Ronald J.</creatorcontrib><creatorcontrib>Alexander, Terry J.</creatorcontrib><creatorcontrib>Umlauf, Anya</creatorcontrib><creatorcontrib>Grant, Igor</creatorcontrib><creatorcontrib>Duiculescu, Dan C.</creatorcontrib><creatorcontrib>Achim, Cristian L.</creatorcontrib><creatorcontrib>Marcotte, Thomas D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurovirology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ene, Luminita</au><au>Franklin, Donald R.</au><au>Burlacu, Ruxandra</au><au>Luca, Anca E.</au><au>Blaglosov, Andreea G.</au><au>Ellis, Ronald J.</au><au>Alexander, Terry J.</au><au>Umlauf, Anya</au><au>Grant, Igor</au><au>Duiculescu, Dan C.</au><au>Achim, Cristian L.</au><au>Marcotte, Thomas D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurocognitive functioning in a Romanian cohort of young adults with parenterally-acquired HIV-infection during childhood</atitle><jtitle>Journal of neurovirology</jtitle><stitle>J. Neurovirol</stitle><addtitle>J Neurovirol</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>20</volume><issue>5</issue><spage>496</spage><epage>504</epage><pages>496-504</pages><issn>1355-0284</issn><eissn>1538-2443</eissn><abstract>The Romanian cohort can provide valuable information about the effect of chronic HIV-infection and exposure to combined antiretroviral therapy (cART) on the developing brain, based on its unique characteristics: young adults infected parenterally with HIV clade F in the late 1980s and exposed to cART for a decade. We conducted a prospective study using a neuropsychological test battery validated in other international HIV cohorts, in order to evaluate the rate and severity of neurocognitive impairment in a group of young Romanian adults. The 49 HIV-infected (HIV+) participants and the 20 HIV negative (HIV−) controls were similar for age and gender, although the HIV− group tended to be more educated. We found higher cognitive impairment prevalence in the HIV+ group (59.1 %) versus the HIV− group (10 %), and the impairment rate remained significantly higher even when the groups were matched based on the educational level (38.7 % for the HIV+ group vs. 10.0 % for the HIV− controls;
p
= 0.025). The nadir CD4 count was <200 in 71.4 % of patients, but at the time of neurocognitive assessment, 89.5 % of patients had normal immunological status and 81.8 % undetectable HIV load. Among the HIV-impaired group, 26 % of the participants had syndromic impairment while the other 74 % had asymptomatic neurocognitive impairment. We found a high prevalence of neurocognitive dysfunction in the Romanian young adults growing-up with HIV. The greatest HIV-related cognitive deficits were in the domains of executive and motor functioning, consistent with a frontosubcortical pattern.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>25185868</pmid><doi>10.1007/s13365-014-0275-1</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1355-0284 |
| ispartof | Journal of neurovirology, 2014-10, Vol.20 (5), p.496-504 |
| issn | 1355-0284 1538-2443 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4324616 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Biomedical and Life Sciences Biomedicine Cognition Disorders - epidemiology Cognition Disorders - virology Cohort Studies Female HIV Infections - complications Human immunodeficiency virus Humans Immunology Infectious Diseases Male Neurology Neuropsychological Tests Neurosciences Prevalence Romania - epidemiology Virology Young Adult |
| title | Neurocognitive functioning in a Romanian cohort of young adults with parenterally-acquired HIV-infection during childhood |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T06%3A43%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neurocognitive%20functioning%20in%20a%20Romanian%20cohort%20of%20young%20adults%20with%20parenterally-acquired%20HIV-infection%20during%20childhood&rft.jtitle=Journal%20of%20neurovirology&rft.au=Ene,%20Luminita&rft.date=2014-10-01&rft.volume=20&rft.issue=5&rft.spage=496&rft.epage=504&rft.pages=496-504&rft.issn=1355-0284&rft.eissn=1538-2443&rft_id=info:doi/10.1007/s13365-014-0275-1&rft_dat=%3Cproquest_pubme%3E1615258060%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1615258060&rft_id=info:pmid/25185868&rfr_iscdi=true |