Identification of Tetrapeptides from a Mixture Based Positional Scanning Library That Can Restore nM Full Agonist Function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin‑4 Polymorphic Receptors (hMC4Rs)

Human obesity has been linked to genetic factors and single nucleotide polymorphisms (SNPs). Melanocortin-4 receptor (MC4R) SNPs have been associated with up to 6% frequency in morbidly obese children and adults. A potential therapy for individuals possessing such genetic modifications is the identi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of medicinal chemistry 2014-06, Vol.57 (11), p.4615-4628
Hauptverfasser: Haslach, Erica M, Huang, Huisuo, Dirain, Marvin, Debevec, Ginamarie, Geer, Phaedra, Santos, Radleigh G, Giulianotti, Marc A, Pinilla, Clemencia, Appel, Jon R, Doering, Skye R, Walters, Michael A, Houghten, Richard A, Haskell-Luevano, Carrie
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!