Survival of dental implants in patients with oral cancer treated by surgery and radiotherapy: a retrospective study
The aim of this retrospective study was to evaluate the survival of dental implants placed after ablative surgery, in patients affected by oral cancer treated with or without radiotherapy. We collected data for 34 subjects (22 females, 12 males; mean age: 51 ± 19) with malignant oral tumors who had...
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| Veröffentlicht in: | BMC oral health 2015-01, Vol.15 (1), p.5-5, Article 5 |
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| creator | Pompa, Giorgio Saccucci, Matteo Di Carlo, Gabriele Brauner, Edoardo Valentini, Valentino Di Carlo, Stefano Gentile, Tina Guarino, Giorgio Polimeni, Antonella |
| description | The aim of this retrospective study was to evaluate the survival of dental implants placed after ablative surgery, in patients affected by oral cancer treated with or without radiotherapy.
We collected data for 34 subjects (22 females, 12 males; mean age: 51 ± 19) with malignant oral tumors who had been treated with ablative surgery and received dental implant rehabilitation between 2007 and 2012. Postoperative radiation therapy (less than 50 Gy) was delivered before implant placement in 12 patients. A total of 144 titanium implants were placed, at a minimum interval of 12 months, in irradiated and non-irradiated residual bone.
Implant loss was dependent on the position and location of the implants (P = 0.05-0.1). Moreover, implant survival was dependent on whether the patient had received radiotherapy. This result was highly statistically significant (P |
| doi_str_mv | 10.1186/1472-6831-15-5 |
| format | Article |
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We collected data for 34 subjects (22 females, 12 males; mean age: 51 ± 19) with malignant oral tumors who had been treated with ablative surgery and received dental implant rehabilitation between 2007 and 2012. Postoperative radiation therapy (less than 50 Gy) was delivered before implant placement in 12 patients. A total of 144 titanium implants were placed, at a minimum interval of 12 months, in irradiated and non-irradiated residual bone.
Implant loss was dependent on the position and location of the implants (P = 0.05-0.1). Moreover, implant survival was dependent on whether the patient had received radiotherapy. This result was highly statistically significant (P < 0.01). Whether the implant was loaded is another highly significant (P < 0.01) factor determining survival. We observed significantly better outcomes when the implant was not loaded until at least 6 months after placement.
Although the retrospective design of this study could be affected by selection and information biases, we conclude that a delayed loading protocol will give the best chance of implant osseointegration, stability and, ultimately, effective dental rehabilitation.</description><identifier>ISSN: 1472-6831</identifier><identifier>EISSN: 1472-6831</identifier><identifier>DOI: 10.1186/1472-6831-15-5</identifier><identifier>PMID: 25599761</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adult ; Aged ; Carcinoma, Squamous Cell - radiotherapy ; Carcinoma, Squamous Cell - surgery ; Care and treatment ; Dental Implantation, Endosseous - methods ; Dental Implants ; Dental Prosthesis Retention ; Dental Prosthesis, Implant-Supported ; Dental Restoration Failure ; Dentistry ; Dose Fractionation ; Female ; Follow-Up Studies ; Health aspects ; Humans ; Jaw Neoplasms - radiotherapy ; Jaw Neoplasms - surgery ; Male ; Mandible - radiation effects ; Mandible - surgery ; Mandibular Neoplasms - radiotherapy ; Mandibular Neoplasms - surgery ; Maxilla - radiation effects ; Maxilla - surgery ; Maxillary Neoplasms - radiotherapy ; Maxillary Neoplasms - surgery ; Middle Aged ; Mouth cancer ; Neoplasm Recurrence, Local - pathology ; Osseointegration - physiology ; Patient outcomes ; Radiotherapy, Adjuvant ; Retrospective Studies ; Survival Analysis ; Treatment Outcome</subject><ispartof>BMC oral health, 2015-01, Vol.15 (1), p.5-5, Article 5</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Pompa et al.; licensee BioMed Central. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-1215d386e7cc3571b58a17391d9990bac0933d766415bb11768c9a517dd06ef13</citedby><cites>FETCH-LOGICAL-c527t-1215d386e7cc3571b58a17391d9990bac0933d766415bb11768c9a517dd06ef13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324417/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324417/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25599761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pompa, Giorgio</creatorcontrib><creatorcontrib>Saccucci, Matteo</creatorcontrib><creatorcontrib>Di Carlo, Gabriele</creatorcontrib><creatorcontrib>Brauner, Edoardo</creatorcontrib><creatorcontrib>Valentini, Valentino</creatorcontrib><creatorcontrib>Di Carlo, Stefano</creatorcontrib><creatorcontrib>Gentile, Tina</creatorcontrib><creatorcontrib>Guarino, Giorgio</creatorcontrib><creatorcontrib>Polimeni, Antonella</creatorcontrib><title>Survival of dental implants in patients with oral cancer treated by surgery and radiotherapy: a retrospective study</title><title>BMC oral health</title><addtitle>BMC Oral Health</addtitle><description>The aim of this retrospective study was to evaluate the survival of dental implants placed after ablative surgery, in patients affected by oral cancer treated with or without radiotherapy.
We collected data for 34 subjects (22 females, 12 males; mean age: 51 ± 19) with malignant oral tumors who had been treated with ablative surgery and received dental implant rehabilitation between 2007 and 2012. Postoperative radiation therapy (less than 50 Gy) was delivered before implant placement in 12 patients. A total of 144 titanium implants were placed, at a minimum interval of 12 months, in irradiated and non-irradiated residual bone.
Implant loss was dependent on the position and location of the implants (P = 0.05-0.1). Moreover, implant survival was dependent on whether the patient had received radiotherapy. This result was highly statistically significant (P < 0.01). Whether the implant was loaded is another highly significant (P < 0.01) factor determining survival. We observed significantly better outcomes when the implant was not loaded until at least 6 months after placement.
Although the retrospective design of this study could be affected by selection and information biases, we conclude that a delayed loading protocol will give the best chance of implant osseointegration, stability and, ultimately, effective dental rehabilitation.</description><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Care and treatment</subject><subject>Dental Implantation, Endosseous - methods</subject><subject>Dental Implants</subject><subject>Dental Prosthesis Retention</subject><subject>Dental Prosthesis, Implant-Supported</subject><subject>Dental Restoration Failure</subject><subject>Dentistry</subject><subject>Dose Fractionation</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Jaw Neoplasms - radiotherapy</subject><subject>Jaw Neoplasms - surgery</subject><subject>Male</subject><subject>Mandible - radiation effects</subject><subject>Mandible - surgery</subject><subject>Mandibular Neoplasms - radiotherapy</subject><subject>Mandibular Neoplasms - surgery</subject><subject>Maxilla - radiation effects</subject><subject>Maxilla - surgery</subject><subject>Maxillary Neoplasms - radiotherapy</subject><subject>Maxillary Neoplasms - surgery</subject><subject>Middle Aged</subject><subject>Mouth cancer</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Osseointegration - physiology</subject><subject>Patient outcomes</subject><subject>Radiotherapy, Adjuvant</subject><subject>Retrospective Studies</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><issn>1472-6831</issn><issn>1472-6831</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptUsFu1DAQtRCIloUrR2SJC5eUTGzHCQekqoIWqRIH4Gw59mTXKImD7WyVv8dRy6pIlQ9-mnnzPDPPhLyF8gKgqT8Cl1VRNwwKEIV4Rs5PgeeP8Bl5FePvsgTZcP6SnFVCtK2s4ZzEH0s4uqMeqO-pxSll5MZ50FOK1E101snhhu9cOlAfctroyWCgKaBOaGm30riEPYaV6snSoK3z6YBBz-snqmnAFHyc0SR3RBrTYtfX5EWvh4hvHu4d-fX1y8-rm-L2-_W3q8vbwohKpgIqEJY1NUpjmJDQiUaDZC3Ytm3LTpuyZczKuuYgug5A1o1ptQBpbVljD2xHPt_rzks3ojV5jty_moMbdViV1079n5ncQe39UXFWcZ6f2pEPDwLB_1kwJjW6aHDI20G_RAW1qHjVlKLK1Pf31L0eULmp91nRbHR1KThwJnjbZtbFE6x8LI7O-Al7l-NPFZi8xBiwP3UPpdo-gNo8VpvHCoQSueDd45lP9H-Os79GqawR</recordid><startdate>20150120</startdate><enddate>20150120</enddate><creator>Pompa, Giorgio</creator><creator>Saccucci, Matteo</creator><creator>Di Carlo, Gabriele</creator><creator>Brauner, Edoardo</creator><creator>Valentini, Valentino</creator><creator>Di Carlo, Stefano</creator><creator>Gentile, Tina</creator><creator>Guarino, Giorgio</creator><creator>Polimeni, Antonella</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150120</creationdate><title>Survival of dental implants in patients with oral cancer treated by surgery and radiotherapy: a retrospective study</title><author>Pompa, Giorgio ; Saccucci, Matteo ; Di Carlo, Gabriele ; Brauner, Edoardo ; Valentini, Valentino ; Di Carlo, Stefano ; Gentile, Tina ; Guarino, Giorgio ; Polimeni, Antonella</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-1215d386e7cc3571b58a17391d9990bac0933d766415bb11768c9a517dd06ef13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Care and treatment</topic><topic>Dental Implantation, Endosseous - methods</topic><topic>Dental Implants</topic><topic>Dental Prosthesis Retention</topic><topic>Dental Prosthesis, Implant-Supported</topic><topic>Dental Restoration Failure</topic><topic>Dentistry</topic><topic>Dose Fractionation</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Jaw Neoplasms - radiotherapy</topic><topic>Jaw Neoplasms - surgery</topic><topic>Male</topic><topic>Mandible - radiation effects</topic><topic>Mandible - surgery</topic><topic>Mandibular Neoplasms - radiotherapy</topic><topic>Mandibular Neoplasms - surgery</topic><topic>Maxilla - radiation effects</topic><topic>Maxilla - surgery</topic><topic>Maxillary Neoplasms - radiotherapy</topic><topic>Maxillary Neoplasms - surgery</topic><topic>Middle Aged</topic><topic>Mouth cancer</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Osseointegration - physiology</topic><topic>Patient outcomes</topic><topic>Radiotherapy, Adjuvant</topic><topic>Retrospective Studies</topic><topic>Survival Analysis</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pompa, Giorgio</creatorcontrib><creatorcontrib>Saccucci, Matteo</creatorcontrib><creatorcontrib>Di Carlo, Gabriele</creatorcontrib><creatorcontrib>Brauner, Edoardo</creatorcontrib><creatorcontrib>Valentini, Valentino</creatorcontrib><creatorcontrib>Di Carlo, Stefano</creatorcontrib><creatorcontrib>Gentile, Tina</creatorcontrib><creatorcontrib>Guarino, Giorgio</creatorcontrib><creatorcontrib>Polimeni, Antonella</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC oral health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pompa, Giorgio</au><au>Saccucci, Matteo</au><au>Di Carlo, Gabriele</au><au>Brauner, Edoardo</au><au>Valentini, Valentino</au><au>Di Carlo, Stefano</au><au>Gentile, Tina</au><au>Guarino, Giorgio</au><au>Polimeni, Antonella</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survival of dental implants in patients with oral cancer treated by surgery and radiotherapy: a retrospective study</atitle><jtitle>BMC oral health</jtitle><addtitle>BMC Oral Health</addtitle><date>2015-01-20</date><risdate>2015</risdate><volume>15</volume><issue>1</issue><spage>5</spage><epage>5</epage><pages>5-5</pages><artnum>5</artnum><issn>1472-6831</issn><eissn>1472-6831</eissn><abstract>The aim of this retrospective study was to evaluate the survival of dental implants placed after ablative surgery, in patients affected by oral cancer treated with or without radiotherapy.
We collected data for 34 subjects (22 females, 12 males; mean age: 51 ± 19) with malignant oral tumors who had been treated with ablative surgery and received dental implant rehabilitation between 2007 and 2012. Postoperative radiation therapy (less than 50 Gy) was delivered before implant placement in 12 patients. A total of 144 titanium implants were placed, at a minimum interval of 12 months, in irradiated and non-irradiated residual bone.
Implant loss was dependent on the position and location of the implants (P = 0.05-0.1). Moreover, implant survival was dependent on whether the patient had received radiotherapy. This result was highly statistically significant (P < 0.01). Whether the implant was loaded is another highly significant (P < 0.01) factor determining survival. We observed significantly better outcomes when the implant was not loaded until at least 6 months after placement.
Although the retrospective design of this study could be affected by selection and information biases, we conclude that a delayed loading protocol will give the best chance of implant osseointegration, stability and, ultimately, effective dental rehabilitation.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>25599761</pmid><doi>10.1186/1472-6831-15-5</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature OA Free Journals; PubMed Central |
| subjects | Adult Aged Carcinoma, Squamous Cell - radiotherapy Carcinoma, Squamous Cell - surgery Care and treatment Dental Implantation, Endosseous - methods Dental Implants Dental Prosthesis Retention Dental Prosthesis, Implant-Supported Dental Restoration Failure Dentistry Dose Fractionation Female Follow-Up Studies Health aspects Humans Jaw Neoplasms - radiotherapy Jaw Neoplasms - surgery Male Mandible - radiation effects Mandible - surgery Mandibular Neoplasms - radiotherapy Mandibular Neoplasms - surgery Maxilla - radiation effects Maxilla - surgery Maxillary Neoplasms - radiotherapy Maxillary Neoplasms - surgery Middle Aged Mouth cancer Neoplasm Recurrence, Local - pathology Osseointegration - physiology Patient outcomes Radiotherapy, Adjuvant Retrospective Studies Survival Analysis Treatment Outcome |
| title | Survival of dental implants in patients with oral cancer treated by surgery and radiotherapy: a retrospective study |
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