Neutrophil serine proteases in antibacterial defense

Highlights • Neutrophil serine proteases (NSPs) support bacterial clearance by neutrophils. • NSPs can kill bacteria, generate antimicrobial peptides or induce NET formation. • The anti-bacterial activities of NSPs are underlined by the discovery of bacterial inhibitors. • Gram-negative bacteria blo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in microbiology 2015-02, Vol.23, p.42-48
Hauptverfasser:	Stapels, Daphne AC, Geisbrecht, Brian V, Rooijakkers, Suzan HM
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology - trends Animals Bacteria - immunology Bacterial Infections - immunology Biomedical Research - trends Host-Pathogen Interactions Humans Immune Evasion Microbiology - trends Neutrophils - enzymology Neutrophils - immunology Neutrophils - microbiology Pathology Serine Proteases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Neutrophil serine proteases (NSPs) support bacterial clearance by neutrophils. • NSPs can kill bacteria, generate antimicrobial peptides or induce NET formation. • The anti-bacterial activities of NSPs are underlined by the discovery of bacterial inhibitors. • Gram-negative bacteria block chymotrypsin-like proteases like NSPs within the periplasm. • Staphylococcus aureus secretes a family of three highly specific NSP inhibitors.
ISSN:	1369-5274 1879-0364
DOI:	10.1016/j.mib.2014.11.002