The effect of ROCK on TNF-α-induced CXCL8 secretion by intestinal epithelial cell lines is mediated through MKK4 and JNK signaling

•Inhibiting ROCK suppressed TNF-stimulated CXCL8 secretion.•Inhibiting ROCK suppressed TNF-stimulated CXCL8 mRNA levels.•Suppressing ROCK had no significant effect on TNF-induced IκBα responses.•Suppressing ROCK inhibited TNF-induced JNK and MKK4 phosphorylation.•ROCK has a role in TNF-induced JNK s...

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Veröffentlicht in:	Cellular immunology 2015-02, Vol.293 (2), p.80-86
Hauptverfasser:	Perey, Aaron C., Weishaar, Isabelle M., McGee, Dennis W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Blotting, Western Caco-2 Cells CXCL8 Enzyme Inhibitors - pharmacology Epithelial Cells - immunology Humans Inflammation - immunology Interleukin-8 - genetics Interleukin-8 - immunology Interleukin-8 - secretion Intestinal epithelial Intestines - cytology Intestines - immunology JNK JNK Mitogen-Activated Protein Kinases - immunology MAP Kinase Kinase 4 - immunology MKK4 Phosphorylation - immunology Pyridines - pharmacology Real-Time Polymerase Chain Reaction rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - immunology RNA Interference - immunology RNA, Messenger - chemistry RNA, Messenger - genetics ROCK Signal Transduction - immunology TNF Tumor Necrosis Factor-alpha - immunology
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