The Effect of Acetoxycycloheximide on Rate of Accumulation of Cerebral Catecholamines from Circulating Tyrosine as Related to its Effect on Memory

The rate of accumulation of newly synthesized catecholamines and endogenous catecholamine levels in mice were determined after an amnestic intracranial dose of acetoxycycloheximide. Rates of accumulation were found to be severely decreased for a period of 12 hr after injection. Total catecholamine l...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1975-02, Vol.72 (2), p.479-482
Hauptverfasser:	Goodman, Richard H., Flexner, Josefa B., Flexner, Louis B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergics Amnesia Anesthetics Animals Brain - drug effects Brain - metabolism Catecholamines Catecholamines - metabolism Cerebral hemispheres Control groups Cycloheximide - analogs & derivatives Cycloheximide - pharmacology Decapitation Dopamine - metabolism Dosage Female Kinetics Memory - drug effects Mice Norepinephrine - metabolism Protein synthesis Radioactive decay Tyrosine - metabolism
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Zusammenfassung:	The rate of accumulation of newly synthesized catecholamines and endogenous catecholamine levels in mice were determined after an amnestic intracranial dose of acetoxycycloheximide. Rates of accumulation were found to be severely decreased for a period of 12 hr after injection. Total catecholamine levels were increased from 1 to 4 hr, then decreased 17 hr following injection. These results are discussed in terms of previous behavioral observations. It is pointed out that they weaken the assumption that acetoxycycloheximide's amnestic effects are solely due to inhibition of protein synthesis.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.72.2.479