Identification of a variant in KDR associated with serum VEGFR2 and pharmacodynamics of Pazopanib

VEGF receptor (VEGFR) kinases are important drug targets in oncology that affect function of systemic endothelial cells. To discover genetic markers that affect VEGFR inhibitor pharmacodynamics, we performed a genome-wide association study of serum soluble vascular VEGFR2 concentrations [sVEGFR2], a...

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Veröffentlicht in:	Clinical cancer research 2015-01, Vol.21 (2), p.365-372
Hauptverfasser:	Maitland, Michael L, Xu, Chun-Fang, Cheng, Yu-Ching, Kistner-Griffin, Emily, Ryan, Kathleen A, Karrison, Theodore G, Das, Soma, Torgerson, Dara, Gamazon, Eric R, Thomeas, Vasiliki, Levine, Matthew R, Wilson, Paul A, Bing, Nan, Liu, Yuan, Cardon, Lon R, Pandite, Lini N, O'Connell, Jeffrey R, Cox, Nancy J, Mitchell, Braxton D, Ratain, Mark J, Shuldiner, Alan R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Angiogenesis Inhibitors - pharmacology Angiogenesis Inhibitors - therapeutic use Carcinoma, Renal Cell - blood Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - genetics Female Genome-Wide Association Study Humans Kidney Neoplasms - blood Kidney Neoplasms - drug therapy Kidney Neoplasms - genetics Male Polymorphism, Single Nucleotide Pyrimidines - pharmacology Pyrimidines - therapeutic use Sulfonamides - pharmacology Sulfonamides - therapeutic use Vascular Endothelial Growth Factor Receptor-2 - blood Vascular Endothelial Growth Factor Receptor-2 - genetics Young Adult
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