Spontaneous and Induced Mutagenesis in Western Equine Encephalomyelitis Virus in Chick Embryo Cells with Different Repair Activity
Evidence was obtained indicating differences in the survival rate of Western equine encephalomyelitis virus after exposure to ultraviolet radiation and methyl methanesulfonate in commercial and leukosisfree chick embryo cells that differed in repair activity. The levels of spontaneous mutagenesis (o...
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| Veröffentlicht in: | Proc. Natl. Acad. Sci. U.S.A., v. 72, no. 1, pp. 386-388 v. 72, no. 1, pp. 386-388, 1975-01, Vol.72 (1), p.386-388 |
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| container_title | Proc. Natl. Acad. Sci. U.S.A., v. 72, no. 1, pp. 386-388 |
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| creator | Dubinin, N. P. Zasukhina, G. D. Nesmashnova, V. A. Lvova, G. N. |
| description | Evidence was obtained indicating differences in the survival rate of Western equine encephalomyelitis virus after exposure to ultraviolet radiation and methyl methanesulfonate in commercial and leukosisfree chick embryo cells that differed in repair activity. The levels of spontaneous mutagenesis (on the basis of the yield of small plaque variants of the encephalomyelitis virus) did not essentially change when the virus was passaged in leukosis-free chick embryo cells, whereas an increase in the number of small plaque variants was observed in the cells of commercial chick embryos. A 10-fold increase in the number of induced virus variants was observed in commercial chick embryo cells in experiments with methyl methanesulfonate as compared with the control, whereas the induction of virus variants was not noted in leukosis-free cells. |
| doi_str_mv | 10.1073/pnas.72.1.386 |
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P. ; Zasukhina, G. D. ; Nesmashnova, V. A. ; Lvova, G. N.</creator><creatorcontrib>Dubinin, N. P. ; Zasukhina, G. D. ; Nesmashnova, V. A. ; Lvova, G. N. ; Inst. of General Genetics, Moscow</creatorcontrib><description>Evidence was obtained indicating differences in the survival rate of Western equine encephalomyelitis virus after exposure to ultraviolet radiation and methyl methanesulfonate in commercial and leukosisfree chick embryo cells that differed in repair activity. The levels of spontaneous mutagenesis (on the basis of the yield of small plaque variants of the encephalomyelitis virus) did not essentially change when the virus was passaged in leukosis-free chick embryo cells, whereas an increase in the number of small plaque variants was observed in the cells of commercial chick embryos. A 10-fold increase in the number of induced virus variants was observed in commercial chick embryo cells in experiments with methyl methanesulfonate as compared with the control, whereas the induction of virus variants was not noted in leukosis-free cells.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.72.1.386</identifier><identifier>PMID: 164025</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Animals ; BIOLOGICAL EFFECTS ; Cells, Cultured ; Chick Embryo ; CHICKENS ; DNA Repair - drug effects ; DNA Repair - radiation effects ; DNA, Viral - metabolism ; Embryonic cells ; EMBRYONIC CELLS- BIOLOGICAL RADIATION EFFECTS ; EMBRYOS ; Encephalitis Virus, Western Equine - metabolism ; Encephalomyelitis ; Genotype ; Hemolytic Plaque Technique ; Horses ; Irradiation ; Kidney cells ; Mesylates ; Mesylates - pharmacology ; MUTAGENESIS- RADIOINDUCTION ; Mutagens ; Mutation - drug effects ; Mutation - radiation effects ; N48210 -Life Sciences-Radiation Effects on Cells- External Source ; Radiation Genetics ; RNA ; SULFONATES ; Survival rates ; SURVIVAL TIME ; ULTRAVIOLET RADIATION ; Ultraviolet Rays ; Viruses ; VIRUSES- MUTAGENESIS</subject><ispartof>Proc. 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U.S.A., v. 72, no. 1, pp. 386-388, 1975-01, Vol.72 (1), p.386-388</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-5f42681a2fbd5cb3047b6da56df74ffdc3cd73e2455736dcd9e405412d6a91a13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/72/1.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/64345$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/64345$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/164025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/4220763$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Dubinin, N. P.</creatorcontrib><creatorcontrib>Zasukhina, G. D.</creatorcontrib><creatorcontrib>Nesmashnova, V. A.</creatorcontrib><creatorcontrib>Lvova, G. N.</creatorcontrib><creatorcontrib>Inst. of General Genetics, Moscow</creatorcontrib><title>Spontaneous and Induced Mutagenesis in Western Equine Encephalomyelitis Virus in Chick Embryo Cells with Different Repair Activity</title><title>Proc. Natl. Acad. Sci. U.S.A., v. 72, no. 1, pp. 386-388</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Evidence was obtained indicating differences in the survival rate of Western equine encephalomyelitis virus after exposure to ultraviolet radiation and methyl methanesulfonate in commercial and leukosisfree chick embryo cells that differed in repair activity. The levels of spontaneous mutagenesis (on the basis of the yield of small plaque variants of the encephalomyelitis virus) did not essentially change when the virus was passaged in leukosis-free chick embryo cells, whereas an increase in the number of small plaque variants was observed in the cells of commercial chick embryos. A 10-fold increase in the number of induced virus variants was observed in commercial chick embryo cells in experiments with methyl methanesulfonate as compared with the control, whereas the induction of virus variants was not noted in leukosis-free cells.</description><subject>Animals</subject><subject>BIOLOGICAL EFFECTS</subject><subject>Cells, Cultured</subject><subject>Chick Embryo</subject><subject>CHICKENS</subject><subject>DNA Repair - drug effects</subject><subject>DNA Repair - radiation effects</subject><subject>DNA, Viral - metabolism</subject><subject>Embryonic cells</subject><subject>EMBRYONIC CELLS- BIOLOGICAL RADIATION EFFECTS</subject><subject>EMBRYOS</subject><subject>Encephalitis Virus, Western Equine - metabolism</subject><subject>Encephalomyelitis</subject><subject>Genotype</subject><subject>Hemolytic Plaque Technique</subject><subject>Horses</subject><subject>Irradiation</subject><subject>Kidney cells</subject><subject>Mesylates</subject><subject>Mesylates - pharmacology</subject><subject>MUTAGENESIS- RADIOINDUCTION</subject><subject>Mutagens</subject><subject>Mutation - drug effects</subject><subject>Mutation - radiation effects</subject><subject>N48210 -Life Sciences-Radiation Effects on Cells- External Source</subject><subject>Radiation Genetics</subject><subject>RNA</subject><subject>SULFONATES</subject><subject>Survival rates</subject><subject>SURVIVAL TIME</subject><subject>ULTRAVIOLET RADIATION</subject><subject>Ultraviolet Rays</subject><subject>Viruses</subject><subject>VIRUSES- MUTAGENESIS</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkTtvFDEUhUeI1xIoaRCFhUQ5i19j7xYpomUDkYKQeJaWx77OOMzag-0J2ZZfzmw2CUGiusX3naMrnap6TvCcYMneDEHnuaRzMmcLca-aEbwkteBLfL-aYUxlveCUP66e5HyOMV42C_yoekgEx7SZVb8_DzEUHSCOGelg0UmwowGLPoxFn0GA7DPyAX2HXCAFtP45-gBoHQwMne7jZgu9L5Pzzafxylx13vxA602bthGtoO8z-uVLh9565yBBKOgTDNondGSKv_Bl-7R64HSf4dn1Pai-Hq-_rN7Xpx_fnayOTmvDpSx14zgVC6Kpa21jWoa5bIXVjbBOcuesYcZKBpQ3jWTCGrsEjhtOqBV6STRhB9XhvncY2w1YM72SdK-G5Dc6bVXUXv1Lgu_UWbxQnFFG8JR_tc_HXLzKxhcwnYkhgCmKU4qlYJNU7yWTYs4J3G0_wWo3l9rNpSRVRE1zTf7Lu0_9ta_2mfDra7xL3cCbtHJj3xe4LHdq_udN-MUen-cS0y0XnPGG_QEoarSO</recordid><startdate>19750101</startdate><enddate>19750101</enddate><creator>Dubinin, N. P.</creator><creator>Zasukhina, G. D.</creator><creator>Nesmashnova, V. A.</creator><creator>Lvova, G. N.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>19750101</creationdate><title>Spontaneous and Induced Mutagenesis in Western Equine Encephalomyelitis Virus in Chick Embryo Cells with Different Repair Activity</title><author>Dubinin, N. P. ; Zasukhina, G. D. ; Nesmashnova, V. A. ; Lvova, G. N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-5f42681a2fbd5cb3047b6da56df74ffdc3cd73e2455736dcd9e405412d6a91a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Animals</topic><topic>BIOLOGICAL EFFECTS</topic><topic>Cells, Cultured</topic><topic>Chick Embryo</topic><topic>CHICKENS</topic><topic>DNA Repair - drug effects</topic><topic>DNA Repair - radiation effects</topic><topic>DNA, Viral - metabolism</topic><topic>Embryonic cells</topic><topic>EMBRYONIC CELLS- BIOLOGICAL RADIATION EFFECTS</topic><topic>EMBRYOS</topic><topic>Encephalitis Virus, Western Equine - metabolism</topic><topic>Encephalomyelitis</topic><topic>Genotype</topic><topic>Hemolytic Plaque Technique</topic><topic>Horses</topic><topic>Irradiation</topic><topic>Kidney cells</topic><topic>Mesylates</topic><topic>Mesylates - pharmacology</topic><topic>MUTAGENESIS- RADIOINDUCTION</topic><topic>Mutagens</topic><topic>Mutation - drug effects</topic><topic>Mutation - radiation effects</topic><topic>N48210 -Life Sciences-Radiation Effects on Cells- External Source</topic><topic>Radiation Genetics</topic><topic>RNA</topic><topic>SULFONATES</topic><topic>Survival rates</topic><topic>SURVIVAL TIME</topic><topic>ULTRAVIOLET RADIATION</topic><topic>Ultraviolet Rays</topic><topic>Viruses</topic><topic>VIRUSES- MUTAGENESIS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dubinin, N. P.</creatorcontrib><creatorcontrib>Zasukhina, G. D.</creatorcontrib><creatorcontrib>Nesmashnova, V. A.</creatorcontrib><creatorcontrib>Lvova, G. N.</creatorcontrib><creatorcontrib>Inst. of General Genetics, Moscow</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proc. Natl. Acad. Sci. U.S.A., v. 72, no. 1, pp. 386-388</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dubinin, N. P.</au><au>Zasukhina, G. D.</au><au>Nesmashnova, V. A.</au><au>Lvova, G. N.</au><aucorp>Inst. of General Genetics, Moscow</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous and Induced Mutagenesis in Western Equine Encephalomyelitis Virus in Chick Embryo Cells with Different Repair Activity</atitle><jtitle>Proc. Natl. Acad. Sci. U.S.A., v. 72, no. 1, pp. 386-388</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1975-01-01</date><risdate>1975</risdate><volume>72</volume><issue>1</issue><spage>386</spage><epage>388</epage><pages>386-388</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Evidence was obtained indicating differences in the survival rate of Western equine encephalomyelitis virus after exposure to ultraviolet radiation and methyl methanesulfonate in commercial and leukosisfree chick embryo cells that differed in repair activity. The levels of spontaneous mutagenesis (on the basis of the yield of small plaque variants of the encephalomyelitis virus) did not essentially change when the virus was passaged in leukosis-free chick embryo cells, whereas an increase in the number of small plaque variants was observed in the cells of commercial chick embryos. A 10-fold increase in the number of induced virus variants was observed in commercial chick embryo cells in experiments with methyl methanesulfonate as compared with the control, whereas the induction of virus variants was not noted in leukosis-free cells.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>164025</pmid><doi>10.1073/pnas.72.1.386</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proc. Natl. Acad. Sci. U.S.A., v. 72, no. 1, pp. 386-388, 1975-01, Vol.72 (1), p.386-388 |
| issn | 0027-8424 1091-6490 |
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| subjects | Animals BIOLOGICAL EFFECTS Cells, Cultured Chick Embryo CHICKENS DNA Repair - drug effects DNA Repair - radiation effects DNA, Viral - metabolism Embryonic cells EMBRYONIC CELLS- BIOLOGICAL RADIATION EFFECTS EMBRYOS Encephalitis Virus, Western Equine - metabolism Encephalomyelitis Genotype Hemolytic Plaque Technique Horses Irradiation Kidney cells Mesylates Mesylates - pharmacology MUTAGENESIS- RADIOINDUCTION Mutagens Mutation - drug effects Mutation - radiation effects N48210 -Life Sciences-Radiation Effects on Cells- External Source Radiation Genetics RNA SULFONATES Survival rates SURVIVAL TIME ULTRAVIOLET RADIATION Ultraviolet Rays Viruses VIRUSES- MUTAGENESIS |
| title | Spontaneous and Induced Mutagenesis in Western Equine Encephalomyelitis Virus in Chick Embryo Cells with Different Repair Activity |
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