Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models

The toxicity of ionizing radiation is associated with massive apoptosis in radiosensitive organs. Here, we investigate whether a drug that activates a signaling mechanism used by tumor cells to suppress apoptosis can protect healthy cells from the harmful effects of radiation. We studied CBLB502, a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 2008-04, Vol.320 (5873), p.226-230
Hauptverfasser:	Burdelya, Lyudmila G, Krivokrysenko, Vadim I, Tallant, Thomas C, Strom, Evguenia, Gleiberman, Anatoly S, Gupta, Damodar, Kurnasov, Oleg V, Fort, Farrel L, Osterman, Andrei L, DiDonato, Joseph A, Feinstein, Elena, Gudkov, Andrei V
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Amino Acid Sequence Animals Antineoplastic agents Apoptosis Apoptosis - drug effects Apoptosis - radiation effects Biological and medical sciences Cellular biology Chemotherapy, Adjuvant Crypts Endothelial cells Flagellin - chemistry Flagellin - pharmacology Gamma Rays General aspects Hematopoietic System - drug effects Hematopoietic System - radiation effects Intestine, Small - cytology Intestine, Small - drug effects Intestine, Small - radiation effects Irradiation Macaca mulatta Medical sciences Mice Mice, Inbred ICR Molecular Sequence Data Neoplasms, Experimental - drug therapy Neoplasms, Experimental - radiotherapy NF-kappa B - metabolism Peptides - administration & dosage Peptides - chemistry Peptides - pharmacology Peptides - toxicity Pharmacology. Drug treatments Primates Radiation Radiation Dosage Radiation Injuries, Experimental - prevention & control Radiation protection Radiation Tolerance - drug effects Radiation-Protective Agents - administration & dosage Radiation-Protective Agents - chemistry Radiation-Protective Agents - pharmacology Radiation-Protective Agents - toxicity Radiotherapy Rodents Salmonella Salmonella enterica Signal Transduction Small intestine Stem cells Toll-Like Receptor 5 - agonists Toll-Like Receptor 5 - metabolism Toxicity Tumors Whole-Body Irradiation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!