Insulin-Like Growth Factor I Stimulates Myofibril Development and Decreases Smooth Muscle α-Actin of Adult Cardiomyocytes

Adult rat cardiomyocytes in long-term culture express type 1 insulin-like growth factor (IGF) receptors. In contrast to insulin receptors, type 1 IGF receptors are up-regulated during culturing. IGF-I added to the cells at plating increased granular density and pseudopodia number per cell after 7 da...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1994-03, Vol.91 (5), p.1686-1690
Hauptverfasser:	Donath, Marc Y., Zapf, Jurgen, Eppenberger-Eberhardt, Monika, Froesch, E. Rudolf, Eppenberger, Hans M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Actins - metabolism Adults Animals Antibodies Biological and medical sciences Cardiomegaly - etiology Cell physiology Cells, Cultured Cultured cells Fundamental and applied biological sciences. Psychology Heart - drug effects Insulin Insulin-Like Growth Factor I - metabolism Insulin-Like Growth Factor I - pharmacology Kinetics Molecular and cellular biology Myocardium Myocardium - cytology Myocardium - metabolism Myofibrils Protein isoforms Rats Receptor, IGF Type 1 - drug effects Receptor, IGF Type 1 - metabolism Receptors Responses to growth factors, tumor promotors, other factors Sarcomeres - drug effects Sarcomeres - ultrastructure Scaffolds Up-Regulation
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