Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine

•Wybutosine is a hypermodified tRNA base.•Biosynthesis of wybutosine requires pyruvate.•TYW1 is a member of the radical SAM superfamily.•TYW1 catalyzes a complex radical-mediated ring formation of the unique tricyclic ring of wybutosine. Wyosine and its derivatives are highly modified, acid labile t...

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Veröffentlicht in:	Current opinion in chemical biology 2013-08, Vol.17 (4), p.613-618
Hauptverfasser:	Young, Anthony P, Bandarian, Vahe
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocatalysis Free Radicals - metabolism Humans Nucleosides - biosynthesis Nucleosides - chemistry RNA, Transfer - metabolism
Online-Zugang:	Volltext
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