Structure-Function Based Molecular Relationships in Ewing’s Sarcoma

Ewing’s Sarcoma Oncogene (ews) on chromosome 22q12 is encoding a ubiquitously expressed RNA-binding protein (EWS) with unknown function that is target of tumor-specific chromosomal translocations in Ewing’s sarcoma family of tumors. A model of transcription complex was proposed in which the heterodi...

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Veröffentlicht in:	BioMed research international 2015-01, Vol.2015 (2015), p.1-15
1. Verfasser:	Todorova, Roumiana
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding proteins Biomedical research Chromosomes Deoxyribonucleic acid DNA Ewing's sarcoma Gene expression Genetic aspects Health aspects Humans Melanoma Methods Models, Molecular Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Pathogenesis Physiological aspects Proteins Review RNA polymerase RNA sequencing RNA-Binding Protein EWS - genetics RNA-Binding Protein EWS - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Sarcoma, Ewing - genetics Sarcoma, Ewing - metabolism Skin cancer Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Tumors
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